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| 1st(1st leg) | Sport Huancayo | - | Liverpool | 1:1 (0:0) | ||
| 2nd (2nd leg) | Liverpool | - | Sport Huancayo | 1:2 (0:1) | ||
| 1st(1st leg): 27/10/2020 22:15 | 2nd (2nd leg): 03/11/2020 22:15 | Winner: Sport Huancayo | ||||
| 1st(1st leg) | Audax Italiano | - | Bolívar | 2:1 (1:1) | ||
| 2nd (2nd leg) | Bolívar | - | Audax Italiano | 3:0 (1:0) | ||
| 1st(1st leg): 27/10/2020 22:15 | 2nd (2nd leg): 03/11/2020 22:15 | Winner: Bolívar | ||||
| 1st(1st leg) | Unión La Calera | - | Deportes Tolima | 0:0 (0:0) | ||
| 2nd (2nd leg) | Deportes Tolima | - | Unión La Calera | 1:1 (1:1) | ||
| 1st(1st leg): 28/10/2020 00:30 | 2nd (2nd leg): 04/11/2020 00:30 | Winner: Unión La Calera | ||||
| 1st(1st leg) | Lanús | - | São Paulo FC | 3:2 (0:1) | ||
| 2nd (2nd leg) | São Paulo FC | - | Lanús | 4:3 (1:2) | ||
| 1st(1st leg): 28/10/2020 22:15 | 2nd (2nd leg): 04/11/2020 22:15 | Winner: Lanús | ||||
| 1st(1st leg) | Sportivo Luqueño | - | Defensa y Justicia | 1:2 (1:1) | ||
| 2nd (2nd leg) | Defensa y Justicia | - | Sportivo Luqueño | 1:1 (0:1) | ||
| 1st(1st leg): 28/10/2020 22:15 | 2nd (2nd leg): 04/11/2020 22:15 | Winner: Defensa y Justicia | ||||
| 1st(1st leg) | Atlético Nacional | - | River Plate | 1:1 (1:0) | ||
| 2nd (2nd leg) | River Plate | - | Atlético Nacional | 3:1 (2:1) | ||
| 1st(1st leg): 28/10/2020 22:15 | 2nd (2nd leg): 04/11/2020 22:15 | Winner: River Plate | ||||
| 1st(1st leg) | Fénix | - | Huachipato | 3:1 (0:0) | ||
| 2nd (2nd leg) | Huachipato | - | Fénix | 1:1 (0:0) | ||
| 1st(1st leg): 28/10/2020 22:15 | 2nd (2nd leg): 04/11/2020 22:15 | Winner: Fénix | ||||
| 1st(1st leg) | Millonarios | - | Deportivo Cali | 1:2 (0:0) | ||
| 2nd (2nd leg) | Deportivo Cali | - | Millonarios | 5:4 (1:1, 1:2) pso | ||
| 1st(1st leg): 29/10/2020 00:30 | 2nd (2nd leg): 05/11/2020 00:30 | Winner: Deportivo Cali | ||||
| 1st(1st leg) | Vasco da Gama - RJ | - | Caracas FC | 1:0 (0:0) | ||
| 2nd (2nd leg) | Caracas FC | - | Vasco da Gama - RJ | 0:0 (0:0) | ||
| 1st(1st leg): 29/10/2020 00:30 | 2nd (2nd leg): 05/11/2020 00:30 | Winner: Vasco da Gama - RJ | ||||
| 1st(1st leg) | Vélez Sarsfield | - | Peñarol | 0:0 (0:0) | ||
| 2nd (2nd leg) | Peñarol | - | Vélez Sarsfield | 1:1 (0:0) | ||
| 1st(1st leg): 29/10/2020 00:30 | 2nd (2nd leg): 05/11/2020 00:30 | Winner: Vélez Sarsfield | ||||
| 1st(1st leg) | Unión de Santa Fe | - | Emelec | 0:1 (0:1) | ||
| 2nd (2nd leg) | Emelec | - | Unión de Santa Fe | 1:2 (0:1) | ||
| 1st(1st leg): 29/10/2020 22:15 | 2nd (2nd leg): 05/11/2020 22:15 | Winner: Unión de Santa Fe | ||||
| 1st(1st leg) | Sol de América | - | Universidad Católica | 0:0 (0:0) | ||
| 2nd (2nd leg) | Universidad Católica | - | Sol de América | 2:1 (0:0) | ||
| 1st(1st leg): 29/10/2020 22:15 | 2nd (2nd leg): 06/11/2020 00:30 | Winner: Universidad Católica | ||||
| 1st(1st leg) | Coquimbo Unido | - | Estudiantes de Mérida | 3:0 (0:0) | ||
| 2nd (2nd leg) | Estudiantes de Mérida | - | Coquimbo Unido | 0:2 (0:1) | ||
| 1st(1st leg): 29/10/2020 22:15 | 2nd (2nd leg): 05/11/2020 22:15 | Winner: Coquimbo Unido | ||||
| 1st(1st leg) | Independiente | - | Atlético Tucumán | 1:0 (1:0) | ||
| 2nd (2nd leg) | Atlético Tucumán | - | Independiente | 1:1 (1:1) | ||
| 1st(1st leg): 30/10/2020 00:30 | 2nd (2nd leg): 06/11/2020 00:30 | Winner: Independiente | ||||
| 1st(1st leg) | Plaza Colonia | - | Atlético Junior | 0:1 (0:0) | ||
| 2nd (2nd leg) | Atlético Junior | - | Plaza Colonia | 0:0 (0:0) | ||
| 1st(1st leg): 30/10/2020 00:30 | 2nd (2nd leg): 06/11/2020 00:30 | Winner: Atlético Junior | ||||
| 1st(1st leg) | FBC Melgar | - | Bahia - BA | 1:0 (0:0) | ||
| 2nd (2nd leg) | Bahia - BA | - | FBC Melgar | 4:0 (4:0) | ||
| 1st(1st leg): 30/10/2020 00:30 | 2nd (2nd leg): 06/11/2020 00:30 | Winner: Bahia - BA | ||||
