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| 09/04/2022 | 11:30 | Bandırmaspor | - | Boluspor | 3:0 (3:0) | |
| 11:30 | Ümraniyespor | - | MKE Ankaragücü | 2:2 (1:1) | ||
| 14:00 | Gençlerbirliği | - | Keçiörengücü | 2:0 (0:0) | ||
| 18:30 | Adanaspor | - | Balıkesirspor | 3:1 (2:1) | ||
| 10/04/2022 | 11:30 | Manisa FK | - | Samsunspor | 2:0 (1:0) | |
| 14:00 | Denizlispor | - | Tuzlaspor | 2:4 (0:2) | ||
| 14:00 | Menemen Belediyespor | - | İstanbulspor AŞ | 1:3 (0:1) | ||
| 18:30 | Bursaspor | - | Kocaelispor | 2:1 (1:1) | ||
| 11/04/2022 | 18:30 | Eyüpspor | - | Altınordu FK | 2:2 (1:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
MKE Ankaragücü | 30 | 18 | 6 | 6 | 47:25 | 22 | 60 |
| 2 |
|
Ümraniyespor | 30 | 17 | 6 | 7 | 50:30 | 20 | 57 |
| 3 |
|
Bandırmaspor | 30 | 17 | 4 | 9 | 46:25 | 21 | 55 |
| 4 |
|
İstanbulspor AŞ | 29 | 15 | 6 | 8 | 47:31 | 16 | 51 |
| 5 |
|
Eyüpspor | 30 | 13 | 11 | 6 | 46:34 | 12 | 50 |
| 6 |
|
BB Erzurumspor | 29 | 13 | 8 | 8 | 46:34 | 12 | 47 |
| 7 |
|
Manisa FK | 30 | 12 | 7 | 11 | 35:35 | 0 | 43 |
| 8 |
|
Samsunspor | 29 | 11 | 9 | 9 | 45:38 | 7 | 42 |
| 9 |
|
Adanaspor | 30 | 11 | 8 | 11 | 35:31 | 4 | 41 |
| 10 |
|
Tuzlaspor | 29 | 10 | 8 | 11 | 29:31 | -2 | 38 |
| 11 |
|
Keçiörengücü | 29 | 10 | 8 | 11 | 36:39 | -3 | 38 |
| 12 |
|
Gençlerbirliği | 29 | 11 | 5 | 13 | 34:42 | -8 | 38 |
| 13 |
|
Boluspor | 29 | 9 | 8 | 12 | 32:36 | -4 | 35 |
| 14 |
|
Menemen Belediyespor | 29 | 8 | 11 | 10 | 37:47 | -10 | 35 |
| 15 |
|
Altınordu FK | 30 | 11 | 2 | 17 | 35:53 | -18 | 35 |
| 16 |
|
Denizlispor | 29 | 9 | 6 | 14 | 33:44 | -11 | 33 |
| 17 |
|
Kocaelispor | 29 | 9 | 6 | 14 | 28:40 | -12 | 33 |
| 18 |
|
Bursaspor | 29 | 8 | 7 | 14 | 32:43 | -11 | 31 |
| 19 |
|
Balıkesirspor | 29 | 3 | 2 | 24 | 22:57 | -35 | 11 |
| Promotion | |
| Playoffs | |
| Relegation |
