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| 30/10/2021 | 11:30 | Bandırmaspor | - | Samsunspor | 2:0 (1:0) | |
| 14:00 | Manisa FK | - | Boluspor | 2:2 (1:0) | ||
| 17:00 | Eyüpspor | - | MKE Ankaragücü | 2:0 (0:0) | ||
| 31/10/2021 | 10:30 | Ümraniyespor | - | Tuzlaspor | 2:1 (1:1) | |
| 13:00 | BB Erzurumspor | - | Balıkesirspor | 2:1 (2:0) | ||
| 16:00 | Denizlispor | - | Kocaelispor | 1:1 (0:1) | ||
| 16:00 | Gençlerbirliği | - | İstanbulspor AŞ | 0:2 (0:1) | ||
| 01/11/2021 | 17:00 | Adanaspor | - | Altınordu FK | 1:0 (0:0) | |
| 17:00 | Bursaspor | - | Keçiörengücü | 2:0 (2:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Ümraniyespor | 11 | 8 | 3 | 0 | 21:4 | 17 | 27 |
| 2 |
|
MKE Ankaragücü | 11 | 7 | 3 | 1 | 19:8 | 11 | 24 |
| 3 |
|
Eyüpspor | 11 | 7 | 2 | 2 | 19:12 | 7 | 23 |
| 4 |
|
BB Erzurumspor | 11 | 7 | 1 | 3 | 17:11 | 6 | 22 |
| 5 |
|
Bandırmaspor | 11 | 7 | 0 | 4 | 20:10 | 10 | 21 |
| 6 |
|
Kocaelispor | 10 | 5 | 2 | 3 | 10:10 | 0 | 17 |
| 7 |
|
Bursaspor | 10 | 4 | 2 | 4 | 14:13 | 1 | 14 |
| 8 |
|
Tuzlaspor | 10 | 4 | 2 | 4 | 10:10 | 0 | 14 |
| 9 |
|
Gençlerbirliği | 10 | 4 | 2 | 4 | 12:16 | -4 | 14 |
| 10 |
|
İstanbulspor AŞ | 10 | 4 | 1 | 5 | 14:13 | 1 | 13 |
| 11 |
|
Boluspor | 10 | 3 | 3 | 4 | 11:11 | 0 | 12 |
| 12 |
|
Samsunspor | 10 | 3 | 3 | 4 | 14:16 | -2 | 12 |
| 13 |
|
Adanaspor | 11 | 3 | 3 | 5 | 13:16 | -3 | 12 |
| 14 |
|
Denizlispor | 10 | 3 | 2 | 5 | 10:13 | -3 | 11 |
| 15 |
|
Menemen Belediyespor | 10 | 3 | 2 | 5 | 12:18 | -6 | 11 |
| 16 |
|
Manisa FK | 11 | 3 | 1 | 7 | 14:20 | -6 | 10 |
| 17 |
|
Altınordu FK | 11 | 3 | 1 | 7 | 12:23 | -11 | 10 |
| 18 |
|
Keçiörengücü | 10 | 2 | 1 | 7 | 8:16 | -8 | 7 |
| 19 |
|
Balıkesirspor | 10 | 2 | 0 | 8 | 7:17 | -10 | 6 |
| Promotion | |
| Playoffs | |
| Relegation |
