11/03/2022 15:00 Ashanti Gold - King Faisal FC 2:0 (1:0)
12/03/2022 15:00 Accra Lions - Dreams FC 1:0 (0:0)
15:00 Berekum Chelsea - Karela United 1:0 (0:0)
13/03/2022 15:00 Aduana Stars - Hearts of Oak 1:0 (1:0)
15:00 Elmina Sharks - Bechem United 2:3 (1:2)
15:00 Great Olympics - Legon Cities 1:0 (1:0)
15:00 Medeama SC - Eleven Wonders 1:0 (0:0)
15:00 WAFA - Real Tamale United 1:0 (1:0)
18:00 Asante Kotoko - Bibiani Gold Stars 5:0 (2:0)
# Team M. W D L goals Dif. Pt.
1 Asante Kotoko, Ghana Asante Kotoko 20 13 5 2 33:10 23 44
2 Aduana Stars, Ghana Aduana Stars 20 11 3 6 27:17 10 36
3 Great Olympics, Ghana Great Olympics 20 9 8 3 20:12 8 35
4 Bechem United, Ghana Bechem United 20 9 7 4 22:11 11 34
5 Medeama SC, Ghana Medeama SC 20 9 5 6 12:11 1 32
6 Hearts of Oak, Ghana Hearts of Oak 20 7 8 5 18:13 5 29
7 Berekum Chelsea, Ghana Berekum Chelsea 20 7 8 5 16:13 3 29
8 King Faisal FC, Ghana King Faisal FC 20 9 2 9 20:20 0 29
9 Karela United, Ghana Karela United 20 7 7 6 24:23 1 28
10 Dreams FC, Ghana Dreams FC 20 7 5 8 31:30 1 26
11 Ashanti Gold, Ghana Ashanti Gold 20 7 4 9 19:22 -3 25
12 Accra Lions, Ghana Accra Lions 20 6 6 8 15:25 -10 24
13 Legon Cities, Ghana Legon Cities 20 5 8 7 17:16 1 23
14 Bibiani Gold Stars, Ghana Bibiani Gold Stars 20 7 2 11 18:26 -8 23
15 Real Tamale United, Ghana Real Tamale United 20 5 6 9 20:25 -5 21
16 WAFA, Ghana WAFA 20 5 6 9 12:19 -7 21
17 Eleven Wonders, Ghana Eleven Wonders 20 5 5 10 17:27 -10 20
18 Elmina Sharks, Ghana Elmina Sharks 20 3 3 14 12:33 -21 12
  Champions League
  Relegation