1st(1st leg) Olympique Lyonnais - ASD Torres Calcio 3:0 (2:0)
2nd (2nd leg) ASD Torres Calcio - Olympique Lyonnais 1:0 (1:0)
1st(1st leg): 10/03/2010 16:30 2nd (2nd leg): 17/03/2010 14:00 Winner: Olympique Lyonnais
1st(1st leg) Umeå IK FF - Montpellier HSC 0:0 (0:0)
2nd (2nd leg) Montpellier HSC - Umeå IK FF 2:2 (0:0)
1st(1st leg): 10/03/2010 18:00 2nd (2nd leg): 17/03/2010 18:00 Winner: Umeå IK FF
1st(1st leg) Turbine Potsdam - Røa IL 5:0 (2:0)
2nd (2nd leg) Røa IL - Turbine Potsdam 0:5 (0:1)
1st(1st leg): 10/03/2010 18:00 2nd (2nd leg): 17/03/2010 14:30 Winner: Turbine Potsdam
1st(1st leg) FCR 2001 Duisburg - Arsenal LFC 2:1 (1:0)
2nd (2nd leg) Arsenal LFC - FCR 2001 Duisburg 0:2 (0:0)
1st(1st leg): 10/03/2010 18:30 2nd (2nd leg): 14/03/2010 13:00 Winner: FCR 2001 Duisburg