 |
 |
|
|
| 1st(1st leg) | Millonarios | - | Fortaleza FC | 3:0 (3:0) | ||
| 2nd (2nd leg) | Fortaleza FC | - | Millonarios | 2:3 (2:2) | ||
| 1st(1st leg): 28/07/2022 00:00 | 2nd (2nd leg): 18/08/2022 02:15 | Winner: Millonarios | ||||
| 1st(1st leg) | Deportes Tolima | - | Independiente Medellín | 1:3 (1:3) | ||
| 2nd (2nd leg) | Independiente Medellín | - | Deportes Tolima | 0:1 (0:0) | ||
| 1st(1st leg): 28/07/2022 02:05 | 2nd (2nd leg): 18/08/2022 00:00 | Winner: Independiente Medellín | ||||
| 1st(1st leg) | La Equidad | - | Unión Magdalena | 1:1 (1:0) | ||
| 2nd (2nd leg) | Unión Magdalena | - | La Equidad | 5:4 (1:0) pso | ||
| 1st(1st leg): 29/07/2022 00:00 | 2nd (2nd leg): 18/08/2022 23:30 | Winner: Unión Magdalena | ||||
| 1st(1st leg) | Atlético Junior | - | Atlético Nacional | 3:0 (1:0) | ||
| 2nd (2nd leg) | Atlético Nacional | - | Atlético Junior | 1:1 (0:0) | ||
| 1st(1st leg): 29/07/2022 02:05 | 2nd (2nd leg): 19/08/2022 02:00 | Winner: Atlético Junior | ||||
