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| 22/04/2022 | 19:30 | VfL Wolfsburg | - | 1. FSV Mainz 05 | 5:0 (5:0) | |
| 23/04/2022 | 14:30 | SpVgg Greuther Fürth | - | Bayer Leverkusen | 1:4 (1:2) | |
| 14:30 | RB Leipzig | - | 1. FC Union Berlin | 1:2 (0:0) | ||
| 14:30 | SC Freiburg | - | Bor. Mönchengladbach | 3:3 (0:2) | ||
| 14:30 | Eintracht Frankfurt | - | 1899 Hoffenheim | 2:2 (1:1) | ||
| 14:30 | 1. FC Köln | - | Arminia Bielefeld | 3:1 (2:1) | ||
| 17:30 | Bayern München | - | Borussia Dortmund | 3:1 (2:0) | ||
| 24/04/2022 | 14:30 | VfL Bochum | - | FC Augsburg | 0:2 (0:2) | |
| 16:30 | Hertha BSC | - | VfB Stuttgart | 2:0 (1:0) |
| » Tables | Home | Away | First round | Second round | First half | Second half |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Bayern München | 31 | 24 | 3 | 4 | 92:30 | 62 | 75 |
| 2 |
|
Borussia Dortmund | 31 | 20 | 3 | 8 | 77:46 | 31 | 63 |
| 3 |
|
Bayer Leverkusen | 31 | 16 | 7 | 8 | 72:44 | 28 | 55 |
| 4 |
|
RB Leipzig | 31 | 16 | 6 | 9 | 66:33 | 33 | 54 |
| 5 |
|
SC Freiburg | 31 | 14 | 10 | 7 | 52:37 | 15 | 52 |
| 6 |
|
1. FC Union Berlin | 31 | 14 | 8 | 9 | 42:40 | 2 | 50 |
| 7 |
|
1. FC Köln | 31 | 13 | 10 | 8 | 47:45 | 2 | 49 |
| 8 |
|
1899 Hoffenheim | 31 | 13 | 7 | 11 | 52:47 | 5 | 46 |
| 9 |
|
Eintracht Frankfurt | 31 | 10 | 10 | 11 | 42:44 | -2 | 40 |
| 10 |
|
1. FSV Mainz 05 | 31 | 11 | 6 | 14 | 43:41 | 2 | 39 |
| 11 |
|
Bor. Mönchengladbach | 31 | 10 | 8 | 13 | 45:58 | -13 | 38 |
| 12 |
|
VfL Wolfsburg | 31 | 11 | 4 | 16 | 39:51 | -12 | 37 |
| 13 |
|
VfL Bochum | 31 | 10 | 6 | 15 | 30:45 | -15 | 36 |
| 14 |
|
FC Augsburg | 31 | 9 | 8 | 14 | 36:47 | -11 | 35 |
| 15 |
|
Hertha BSC | 31 | 9 | 5 | 17 | 34:66 | -32 | 32 |
| 16 |
|
VfB Stuttgart | 31 | 6 | 10 | 15 | 36:55 | -19 | 28 |
| 17 |
|
Arminia Bielefeld | 31 | 5 | 11 | 15 | 24:49 | -25 | 26 |
| 18 |
|
SpVgg Greuther Fürth | 31 | 3 | 8 | 20 | 25:76 | -51 | 17 |
| Champions League | |
| Europa League | |
| Playoffs | |
| Relegation |
