FA Cup   M. W D L goals
  at home 1 1 0 0 4 : 1
  Away 2 1 1 0 1 : 0
  3 2 1 0 5 : 1
League Cup   M. W D L goals
  Away 1 1 0 0 2 : 1
  1 1 0 0 2 : 1
League One   M. W D L goals
  at home 7 3 0 4 8 : 10
  Away 7 1 1 5 6 : 11
  14 4 1 9 14 : 21
League Two   M. W D L goals
  at home 5 0 2 3 4 : 9
  Away 5 2 1 2 10 : 7
  10 2 3 5 14 : 16
EFL Trophy   M. W D L goals
  at home 1 0 0 0 :
  1 0 0 0 :
overall   M. W D L goals
  at home 14 4 2 7 16 : 20
  Away 15 5 3 7 19 : 19
  Neutral Place 0 0 0 0 0 : 0
  29 9 5 14 35 : 39
FA Cup
2008/2009 1. Round Colchester United - Leyton Orient 0:1 (0:0)
1990/1991 2. Round Leyton Orient - Colchester United 4:1
1990/1991 2. Round Colchester United - Leyton Orient 0:0 (0:0)
League Cup
2009/2010 1. Round Colchester United - Leyton Orient 1:2 (0:1)
League One
2014/2015 27. Round Colchester United - Leyton Orient 2:0 (1:0)
2014/2015 7. Round Leyton Orient - Colchester United 0:2 (0:0)
2013/2014 34. Round Leyton Orient - Colchester United 2:1 (1:0)
2013/2014 5. Round Colchester United - Leyton Orient 1:2 (1:1)
2012/2013 43. Round Colchester United - Leyton Orient 2:1 (2:1)
2012/2013 14. Round Leyton Orient - Colchester United 0:2 (0:1)
2011/2012 28. Round Leyton Orient - Colchester United 0:1 (0:1)
2011/2012 7. Round Colchester United - Leyton Orient 1:1 (1:0)
2010/2011 25. Round Leyton Orient - Colchester United 4:2 (1:0)
2010/2011 15. Round Colchester United - Leyton Orient 3:2 (2:2)
2009/2010 46. Round Colchester United - Leyton Orient 1:0 (0:0)
2009/2010 12. Round Leyton Orient - Colchester United 0:1 (0:0)
2008/2009 42. Round Leyton Orient - Colchester United 2:1 (1:1)
2008/2009 23. Round Colchester United - Leyton Orient 1:0 (1:0)
League Two
2022/2023 37. Round Leyton Orient - Colchester United 2:2 (1:0)
2022/2023 5. Round Colchester United - Leyton Orient 1:3 (0:1)
2021/2022 23. Round Colchester United - Leyton Orient 2:2 (0:0)
2021/2022 30. Round Leyton Orient - Colchester United 0:1 (0:1)
2020/2021 28. Round Leyton Orient - Colchester United 0:0 (0:0)
2020/2021 12. Round Colchester United - Leyton Orient 2:1 (1:0)
2019/2020 23. Round Leyton Orient - Colchester United 1:3 (0:1)
2019/2020 10. Round Colchester United - Leyton Orient 2:1 (2:1)
2016/2017 45. Round Leyton Orient - Colchester United 1:3 (0:1)
2016/2017 16. Round Colchester United - Leyton Orient 0:3 (0:1)
EFL Trophy
2024/2025 Group E South Leyton Orient - Colchester United 4:2 (1:0, 1:1) pso

For games that were decided on penalties the score after 120 minutes will be included in the ranking