| Copa Sudamericana | M. | W | D | L | goals | |||
| at home | 1 | 0 | 1 | 0 | 1 | : | 1 | |
| Away | 1 | 0 | 0 | 1 | 1 | : | 2 | |
| ∑ | 2 | 0 | 1 | 1 | 2 | : | 3 | |
| Primera División | M. | W | D | L | goals | |||
| at home | 22 | 8 | 5 | 9 | 20 | : | 27 | |
| Away | 24 | 3 | 5 | 16 | 19 | : | 42 | |
| ∑ | 46 | 11 | 10 | 25 | 39 | : | 69 | |
| Copa de la Liga Profesional | M. | W | D | L | goals | |||
| Away | 1 | 0 | 1 | 0 | 1 | : | 1 | |
| ∑ | 1 | 0 | 1 | 0 | 1 | : | 1 | |
| overall | M. | W | D | L | goals | |||
| at home | 23 | 8 | 6 | 9 | 21 | : | 28 | |
| Away | 26 | 3 | 6 | 17 | 21 | : | 45 | |
| Neutral Place | 0 | 0 | 0 | 0 | 0 | : | 0 | |
| ∑ | 49 | 11 | 12 | 26 | 42 | : | 73 | |
| Copa Sudamericana | |||||
| 2003 | Round of 16 | Boca Juniors | - | Colón de Santa Fe | 2:1 (0:0) |
| 2003 | Round of 16 | Colón de Santa Fe | - | Boca Juniors | 1:1 (0:1) |
| Copa de la Liga Profesional | |||||
| 2022 | 1. Round | Boca Juniors | - | Colón de Santa Fe | 1:1 (1:0) |
|
For games that were decided on penalties the score after 120 minutes will be included in the ranking |
Argentina 
![Colón de Santa Fe [U20]](https://s.hs-data.com/bilder/wappen/mini/26341.gif?fallback=png "Colón de Santa Fe [U20]"){kind=small}
![Colón de Santa Fe [U16]](https://s.hs-data.com/bilder/wappen/mini/29635.gif?fallback=png "Colón de Santa Fe [U16]"){kind=small}
