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| 28/08/2022 | 01:00 | La Luz | - | Progreso | 1:1 (1:1) | |
| 14:00 | Sud América | - | Juventud de Las Piedras | 0:2 (0:2) | ||
| 16:30 | CA Cerro | - | Racing | 0:0 (0:0) | ||
| 19:15 | Central Español | - | Villa Española | 2:0 (0:0) | ||
| 29/08/2022 | 00:30 | Miramar Misiones | - | Uruguay Montevideo | 0:0 (0:0) | |
| 16:30 | Atenas | - | Rampla Juniors | 1:1 (1:1) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Racing | 18 | 11 | 5 | 2 | 23:8 | 15 | 38 |
| 2 |
|
CA Cerro | 18 | 9 | 5 | 4 | 22:16 | 6 | 32 |
| 3 |
|
La Luz | 18 | 7 | 9 | 2 | 23:15 | 8 | 30 |
| 4 |
|
Uruguay Montevideo | 18 | 8 | 5 | 5 | 23:20 | 3 | 29 |
| 5 |
|
Miramar Misiones | 18 | 6 | 7 | 5 | 25:20 | 5 | 25 |
| 6 |
|
Atenas | 18 | 4 | 7 | 7 | 15:17 | -2 | 22 |
| 7 |
|
Juventud de Las Piedras | 18 | 5 | 6 | 7 | 13:16 | -3 | 21 |
| 8 |
|
Villa Española | 18 | 5 | 6 | 7 | 18:22 | -4 | 21 |
| 9 |
|
Sud América | 18 | 5 | 5 | 8 | 15:25 | -10 | 20 |
| 10 |
|
Rampla Juniors | 18 | 5 | 3 | 10 | 15:23 | -8 | 18 |
| 11 |
|
Central Español | 18 | 4 | 8 | 6 | 17:19 | -2 | 17 |
| 12 |
|
Progreso | 18 | 2 | 8 | 8 | 11:19 | -8 | 14 |
