 |
 |
|
| 1st(1st leg) | Progreso | - | Defensor Sporting | 1:1 (0:0) | ||
| 2nd (2nd leg) | Defensor Sporting | - | Progreso | 3:1 (0:1) | ||
| 1st(1st leg): 26/10/2022 20:30 | 2nd (2nd leg): 03/11/2022 23:00 | Winner: Defensor Sporting | ||||
| 1st(1st leg) | Peñarol | - | La Luz | 1:0 (0:0) | ||
| 2nd (2nd leg) | La Luz | - | Peñarol | 4:2 (0:0, 1:0) pso | ||
| 1st(1st leg): 28/10/2022 00:00 | 2nd (2nd leg): 01/11/2022 23:00 | Winner: La Luz | ||||
