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| 1st(1st leg) | Shakhtar Donetsk | - | Olympique Marseille | 2:0 (1:0) | ||
| 2nd (2nd leg) | Olympique Marseille | - | Shakhtar Donetsk | 1:2 (1:1) | ||
| 1st(1st leg): 09/04/2009 17:30 | 2nd (2nd leg): 16/04/2009 19:45 | Winner: Shakhtar Donetsk | ||||
| 1st(1st leg) | Hamburger SV | - | Manchester City | 3:1 (1:1) | ||
| 2nd (2nd leg) | Manchester City | - | Hamburger SV | 2:1 (1:1) | ||
| 1st(1st leg): 09/04/2009 19:45 | 2nd (2nd leg): 16/04/2009 19:45 | Winner: Hamburger SV | ||||
| 1st(1st leg) | Paris Saint-Germain | - | Dinamo Kiev | 0:0 (0:0) | ||
| 2nd (2nd leg) | Dinamo Kiev | - | Paris Saint-Germain | 3:0 (2:0) | ||
| 1st(1st leg): 09/04/2009 19:45 | 2nd (2nd leg): 16/04/2009 17:30 | Winner: Dinamo Kiev | ||||
| 1st(1st leg) | Werder Bremen | - | Udinese Calcio | 3:1 (1:0) | ||
| 2nd (2nd leg) | Udinese Calcio | - | Werder Bremen | 3:3 (3:1) | ||
| 1st(1st leg): 09/04/2009 19:45 | 2nd (2nd leg): 16/04/2009 19:45 | Winner: Werder Bremen | ||||
