1st(1st leg) Partizan - Dnipro Dnipropetrovsk 2:2 (2:1)
2nd (2nd leg) Dnipro Dnipropetrovsk - Partizan 0:1 (0:0)
1st(1st leg): 16/02/2005 16:00 2nd (2nd leg): 24/02/2005 16:00 Winner: Partizan
1st(1st leg) Shakhtar Donetsk - FC Schalke 04 1:1 (0:1)
2nd (2nd leg) FC Schalke 04 - Shakhtar Donetsk 0:1 (0:1)
1st(1st leg): 16/02/2005 17:15 2nd (2nd leg): 24/02/2005 17:00 Winner: Shakhtar Donetsk
1st(1st leg) Panathinaikos - Sevilla FC 1:0 (0:0)
2nd (2nd leg) Sevilla FC - Panathinaikos 2:0 (0:0)
1st(1st leg): 16/02/2005 18:00 2nd (2nd leg): 24/02/2005 20:30 Winner: Sevilla FC
1st(1st leg) AFC Ajax - AJ Auxerre 1:0 (1:0)
2nd (2nd leg) AJ Auxerre - AFC Ajax 3:1 (1:1)
1st(1st leg): 16/02/2005 19:00 2nd (2nd leg): 24/02/2005 19:45 Winner: AJ Auxerre
1st(1st leg) Parma FC - VfB Stuttgart 0:0 (0:0)
2nd (2nd leg) VfB Stuttgart - Parma FC 0:2 (0:0, 0:0) aet
1st(1st leg): 16/02/2005 19:30 2nd (2nd leg): 24/02/2005 19:30 Winner: Parma FC
1st(1st leg) Valencia CF - FC Steaua Bucureşti 2:0 (1:0)
2nd (2nd leg) FC Steaua Bucureşti - Valencia CF 4:3 (0:0, 2:0, 2:0) pso
1st(1st leg): 16/02/2005 20:30 2nd (2nd leg): 24/02/2005 18:00 Winner: FC Steaua Bucureşti
1st(1st leg) Sporting CP - Feyenoord 2:1 (2:1)
2nd (2nd leg) Feyenoord - Sporting CP 1:2 (0:0)
1st(1st leg): 16/02/2005 21:15 2nd (2nd leg): 24/02/2005 19:45 Winner: Sporting CP
1st(1st leg) Dinamo Kiev - Villarreal CF 0:0 (0:0)
2nd (2nd leg) Villarreal CF - Dinamo Kiev 2:0 (2:0)
1st(1st leg): 17/02/2005 16:00 2nd (2nd leg): 24/02/2005 20:30 Winner: Villarreal CF
1st(1st leg) Grazer AK - Middlesbrough FC 2:2 (0:0)
2nd (2nd leg) Middlesbrough FC - Grazer AK 2:1 (1:1)
1st(1st leg): 17/02/2005 17:30 2nd (2nd leg): 24/02/2005 20:00 Winner: Middlesbrough FC
1st(1st leg) CSKA Moskva - SL Benfica 2:0 (1:0)
2nd (2nd leg) SL Benfica - CSKA Moskva 1:1 (0:0)
1st(1st leg): 17/02/2005 18:00 2nd (2nd leg): 24/02/2005 20:30 Winner: CSKA Moskva
1st(1st leg) Fenerbahçe - Real Zaragoza 0:1 (0:0)
2nd (2nd leg) Real Zaragoza - Fenerbahçe 2:1 (1:0)
1st(1st leg): 17/02/2005 18:00 2nd (2nd leg): 24/02/2005 19:45 Winner: Real Zaragoza
1st(1st leg) FC Basel 1893 - Lille OSC 0:0 (0:0)
2nd (2nd leg) Lille OSC - FC Basel 1893 2:0 (1:0)
1st(1st leg): 17/02/2005 19:30 2nd (2nd leg): 24/02/2005 20:00 Winner: Lille OSC
1st(1st leg) Alemannia Aachen - AZ Alkmaar 0:0 (0:0)
2nd (2nd leg) AZ Alkmaar - Alemannia Aachen 2:1 (0:1)
1st(1st leg): 17/02/2005 19:30 2nd (2nd leg): 24/02/2005 17:30 Winner: AZ Alkmaar
1st(1st leg) sc Heerenveen - Newcastle United 1:2 (1:0)
2nd (2nd leg) Newcastle United - sc Heerenveen 2:1 (2:0)
1st(1st leg): 17/02/2005 19:45 2nd (2nd leg): 24/02/2005 19:45 Winner: Newcastle United
1st(1st leg) Olympiakos Piraeus - FC Sochaux 1:0 (1:0)
2nd (2nd leg) FC Sochaux - Olympiakos Piraeus 0:1 (0:0)
1st(1st leg): 17/02/2005 19:45 2nd (2nd leg): 24/02/2005 18:00 Winner: Olympiakos Piraeus
1st(1st leg) Austria Wien - Athletic Club 0:0 (0:0)
2nd (2nd leg) Athletic Club - Austria Wien 1:2 (1:1)
1st(1st leg): 24/02/2005 18:30 2nd (2nd leg): 27/02/2005 17:00 Winner: Austria Wien