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| 1st(1st leg) | Eintracht Frankfurt | - | FC Sochaux | 4:2 (2:0) | ||
| 2nd (2nd leg) | FC Sochaux | - | Eintracht Frankfurt | 2:0 (2:0) | ||
| 1st(1st leg): 26/11/1980 | 2nd (2nd leg): 10/12/1980 | Winner: FC Sochaux | ||||
| 1st(1st leg) | Hamburger SV | - | AS Saint-Étienne | 0:5 (0:3) | ||
| 2nd (2nd leg) | AS Saint-Étienne | - | Hamburger SV | 1:0 (1:0) | ||
| 1st(1st leg): 26/11/1980 | 2nd (2nd leg): 10/12/1980 | Winner: AS Saint-Étienne | ||||
| 1st(1st leg) | VfB Stuttgart | - | 1. FC Köln | 3:1 (2:1) | ||
| 2nd (2nd leg) | 1. FC Köln | - | VfB Stuttgart | 4:1 (1:0, 3:1) aet | ||
| 1st(1st leg): 26/11/1980 | 2nd (2nd leg): 10/12/1980 | Winner: 1. FC Köln | ||||
| 1st(1st leg) | Sporting Lokeren | - | Real Sociedad | 1:0 (0:0) | ||
| 2nd (2nd leg) | Real Sociedad | - | Sporting Lokeren | 2:2 (0:1) | ||
| 1st(1st leg): 26/11/1980 | 2nd (2nd leg): 10/12/1980 | Winner: Sporting Lokeren | ||||
| 1st(1st leg) | Grasshopper Club Zürich | - | Torino FC | 2:1 (0:0) | ||
| 2nd (2nd leg) | Torino FC | - | Grasshopper Club Zürich | 3:4 (0:1, 2:1, 2:1) pso | ||
| 1st(1st leg): 26/11/1980 | 2nd (2nd leg): 10/12/1980 | Winner: Grasshopper Club Zürich | ||||
| 1st(1st leg) | Radnički Niš | - | AZ '67 Alkmaar | 2:2 (0:1) | ||
| 2nd (2nd leg) | AZ '67 Alkmaar | - | Radnički Niš | 5:0 (3:0) | ||
| 1st(1st leg): 26/11/1980 | 2nd (2nd leg): 10/12/1980 | Winner: AZ '67 Alkmaar | ||||
| 1st(1st leg) | Standard Liège | - | Dynamo Dresden | 1:1 (0:1) | ||
| 2nd (2nd leg) | Dynamo Dresden | - | Standard Liège | 1:4 (0:2) | ||
| 1st(1st leg): 26/11/1980 | 2nd (2nd leg): 10/12/1980 | Winner: Standard Liège | ||||
| 1st(1st leg) | Ipswich Town | - | Widzew Łódź | 5:0 (3:0) | ||
| 2nd (2nd leg) | Widzew Łódź | - | Ipswich Town | 1:0 (0:0) | ||
| 1st(1st leg): 26/11/1980 | 2nd (2nd leg): 10/12/1980 | Winner: Ipswich Town | ||||
