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| 1st(1st leg) | Levski Sofia | - | AZ '67 Alkmaar | 1:1 (0:0) | ||
| 2nd (2nd leg) | AZ '67 Alkmaar | - | Levski Sofia | 5:0 (1:0) | ||
| 1st(1st leg): 21/10/1980 | 2nd (2nd leg): 04/11/1980 | Winner: AZ '67 Alkmaar | ||||
| 1st(1st leg) | FC Sochaux | - | Boavista | 2:2 (1:1) | ||
| 2nd (2nd leg) | Boavista | - | FC Sochaux | 0:1 (0:0) | ||
| 1st(1st leg): 22/10/1980 | 2nd (2nd leg): 05/11/1980 | Winner: FC Sochaux | ||||
| 1st(1st leg) | St. Mirren FC | - | AS Saint-Étienne | 0:0 (0:0) | ||
| 2nd (2nd leg) | AS Saint-Étienne | - | St. Mirren FC | 2:0 (1:0) | ||
| 1st(1st leg): 22/10/1980 | 2nd (2nd leg): 05/11/1980 | Winner: AS Saint-Étienne | ||||
| 1st(1st leg) | Torino FC | - | 1. FC Magdeburg | 3:1 (1:0) | ||
| 2nd (2nd leg) | 1. FC Magdeburg | - | Torino FC | 1:0 (1:0) | ||
| 1st(1st leg): 22/10/1980 | 2nd (2nd leg): 05/11/1980 | Winner: Torino FC | ||||
| 1st(1st leg) | FC Twente | - | Dynamo Dresden | 1:1 (1:0) | ||
| 2nd (2nd leg) | Dynamo Dresden | - | FC Twente | 0:0 (0:0) | ||
| 1st(1st leg): 22/10/1980 | 2nd (2nd leg): 05/11/1980 | Winner: Dynamo Dresden | ||||
| 1st(1st leg) | Widzew Łódź | - | Juventus | 3:1 (1:1) | ||
| 2nd (2nd leg) | Juventus | - | Widzew Łódź | 1:4 (1:0, 3:1, 3:1) pso | ||
| 1st(1st leg): 22/10/1980 | 2nd (2nd leg): 05/11/1980 | Winner: Widzew Łódź | ||||
| 1st(1st leg) | Dundee United | - | Sporting Lokeren | 1:1 (0:0) | ||
| 2nd (2nd leg) | Sporting Lokeren | - | Dundee United | 0:0 (0:0) | ||
| 1st(1st leg): 22/10/1980 | 2nd (2nd leg): 05/11/1980 | Winner: Sporting Lokeren | ||||
| 1st(1st leg) | FC Utrecht | - | Eintracht Frankfurt | 2:1 (0:1) | ||
| 2nd (2nd leg) | Eintracht Frankfurt | - | FC Utrecht | 3:1 (0:0) | ||
| 1st(1st leg): 22/10/1980 | 2nd (2nd leg): 05/11/1980 | Winner: Eintracht Frankfurt | ||||
| 1st(1st leg) | Ipswich Town | - | TJ Bohemians ČKD Praha | 3:0 (0:0) | ||
| 2nd (2nd leg) | TJ Bohemians ČKD Praha | - | Ipswich Town | 2:0 (1:0) | ||
| 1st(1st leg): 22/10/1980 | 2nd (2nd leg): 05/11/1980 | Winner: Ipswich Town | ||||
| 1st(1st leg) | PSV Eindhoven | - | Hamburger SV | 1:1 (0:1) | ||
| 2nd (2nd leg) | Hamburger SV | - | PSV Eindhoven | 2:1 (0:0) | ||
| 1st(1st leg): 22/10/1980 | 2nd (2nd leg): 05/11/1980 | Winner: Hamburger SV | ||||
| 1st(1st leg) | 1. FC Köln | - | FC Barcelona | 0:1 (0:1) | ||
| 2nd (2nd leg) | FC Barcelona | - | 1. FC Köln | 0:4 (0:1) | ||
| 1st(1st leg): 22/10/1980 | 2nd (2nd leg): 05/11/1980 | Winner: 1. FC Köln | ||||
| 1st(1st leg) | VfB Stuttgart | - | FC Vorwärts Frankfurt/Oder | 5:1 (2:0) | ||
| 2nd (2nd leg) | FC Vorwärts Frankfurt/Oder | - | VfB Stuttgart | 1:2 (0:1) | ||
| 1st(1st leg): 22/10/1980 | 2nd (2nd leg): 05/11/1980 | Winner: VfB Stuttgart | ||||
| 1st(1st leg) | 1. FC Kaiserslautern | - | Standard Liège | 1:2 (1:1) | ||
| 2nd (2nd leg) | Standard Liège | - | 1. FC Kaiserslautern | 2:1 (1:1) | ||
| 1st(1st leg): 22/10/1980 | 2nd (2nd leg): 05/11/1980 | Winner: Standard Liège | ||||
| 1st(1st leg) | PFC Beroe | - | Radnički Niš | 0:1 (0:0) | ||
| 2nd (2nd leg) | Radnički Niš | - | PFC Beroe | 2:1 (1:0) | ||
| 1st(1st leg): 22/10/1980 | 2nd (2nd leg): 05/11/1980 | Winner: Radnički Niš | ||||
| 1st(1st leg) | TJ Zbrojovka Brno | - | Real Sociedad | 1:1 (0:0) | ||
| 2nd (2nd leg) | Real Sociedad | - | TJ Zbrojovka Brno | 2:1 (2:0) | ||
| 1st(1st leg): 22/10/1980 | 2nd (2nd leg): 05/11/1980 | Winner: Real Sociedad | ||||
| 1st(1st leg) | FC Porto | - | Grasshopper Club Zürich | 2:0 (1:0) | ||
| 2nd (2nd leg) | Grasshopper Club Zürich | - | FC Porto | 3:0 (1:0, 2:0) aet | ||
| 1st(1st leg): 22/10/1980 | 2nd (2nd leg): 05/11/1980 | Winner: Grasshopper Club Zürich | ||||
