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| 20/04/2019 | 15:00 | Houston Dynamo | - | Deportivo Toluca | 1:2 | |
| 15:00 | Atlanta United FC | - | Fjölnir Reykjavík | 3:0 | ||
| 15:00 | Colorado Rapids | - | D.C. United | 1:3 pso | ||
| 15:00 | Columbus Crew | - | Vancouver Whitecaps | 1:5 | ||
| 16:30 | Philadelphia Union | - | Ulsan HD FC | 1:4 | ||
| 17:05 | New England Revolution | - | San Jose Earthquakes | 2:3 | ||
| 17:05 | Mount Pleasant Academy | - | Orlando City | 0:2 | ||
| 17:05 | Chicago Fire | - | CF Monterrey | 1:0 | ||
| 18:00 | Sporting Kansas City | - | Portland Timbers | 5:6 pso |
