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| 1st(1st leg) | Kayserispor | - | Akhisar Belediyespor | 1:2 (0:2) | ||
| 2nd (2nd leg) | Akhisar Belediyespor | - | Kayserispor | 0:0 (0:0) | ||
| 1st(1st leg): 15/01/2019 13:00 | 2nd (2nd leg): 22/01/2019 15:00 | Winner: Akhisar Belediyespor | ||||
| 1st(1st leg) | Antalyaspor | - | Göztepe | 3:3 (2:0) | ||
| 2nd (2nd leg) | Göztepe | - | Antalyaspor | 3:0 (2:0) | ||
| 1st(1st leg): 15/01/2019 15:00 | 2nd (2nd leg): 23/01/2019 15:00 | Winner: Göztepe | ||||
| 1st(1st leg) | Yeni Malatyaspor | - | Bodrum Belediyesi | 3:2 (0:2) | ||
| 2nd (2nd leg) | Bodrum Belediyesi | - | Yeni Malatyaspor | 1:2 (0:0) | ||
| 1st(1st leg): 16/01/2019 13:30 | 2nd (2nd leg): 23/01/2019 11:00 | Winner: Yeni Malatyaspor | ||||
| 1st(1st leg) | İstanbul Başakşehir | - | Hatayspor | 1:0 (1:0) | ||
| 2nd (2nd leg) | Hatayspor | - | İstanbul Başakşehir | 4:1 (3:1) | ||
| 1st(1st leg): 16/01/2019 15:30 | 2nd (2nd leg): 24/01/2019 10:00 | Winner: Hatayspor | ||||
| 1st(1st leg) | Trabzonspor | - | Balıkesirspor | 2:1 (1:0) | ||
| 2nd (2nd leg) | Balıkesirspor | - | Trabzonspor | 1:3 (1:1) | ||
| 1st(1st leg): 16/01/2019 17:30 | 2nd (2nd leg): 23/01/2019 17:30 | Winner: Trabzonspor | ||||
| 1st(1st leg) | Alanyaspor | - | Kasımpaşa SK | 0:0 (0:0) | ||
| 2nd (2nd leg) | Kasımpaşa SK | - | Alanyaspor | 1:0 (0:0, 0:0) aet | ||
| 1st(1st leg): 17/01/2019 15:30 | 2nd (2nd leg): 24/01/2019 15:00 | Winner: Kasımpaşa SK | ||||
| 1st(1st leg) | Ümraniyespor | - | Fenerbahçe | 1:0 (0:0) | ||
| 2nd (2nd leg) | Fenerbahçe | - | Ümraniyespor | 0:1 (0:0) | ||
| 1st(1st leg): 17/01/2019 17:30 | 2nd (2nd leg): 24/01/2019 17:30 | Winner: Ümraniyespor | ||||
| 1st(1st leg) | Boluspor | - | Galatasaray | 0:1 (0:1) | ||
| 2nd (2nd leg) | Galatasaray | - | Boluspor | 4:1 (2:0) | ||
| 1st(1st leg): 22/01/2019 16:45 | 2nd (2nd leg): 29/01/2019 16:45 | Winner: Galatasaray | ||||
