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| 1st(1st leg) | Dragón | - | FAS | 3:2 (1:1) | ||
| 2nd (2nd leg) | FAS | - | Dragón | 3:1 (1:0) | ||
| 1st(1st leg): 26/10/2022 22:00 | 2nd (2nd leg): 30/10/2022 21:00 | Winner: FAS | ||||
| 1st(1st leg) | Platense Zacatecoluca | - | Alianza | 1:1 (0:0) | ||
| 2nd (2nd leg) | Alianza | - | Platense Zacatecoluca | 0:1 (0:1) | ||
| 1st(1st leg): 26/10/2022 22:00 | 2nd (2nd leg): 30/10/2022 21:15 | Winner: Platense Zacatecoluca | ||||
| 1st(1st leg) | Atlético Marte | - | CD Águila | 0:0 (0:0) | ||
| 2nd (2nd leg) | CD Águila | - | Atlético Marte | 1:0 (0:0) | ||
| 1st(1st leg): 27/10/2022 02:30 | 2nd (2nd leg): 30/10/2022 21:00 | Winner: CD Águila | ||||
| 1st(1st leg) | Isidro Metapán | - | Jocoro FC | 1:1 (1:0) | ||
| 2nd (2nd leg) | Jocoro FC | - | Isidro Metapán | 4:2 (0:0, 0:0) pso | ||
| 1st(1st leg): 28/10/2022 02:30 | 2nd (2nd leg): 30/10/2022 21:00 | Winner: Jocoro FC | ||||
