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| 1st(1st leg) | Luis Ángel Firpo | - | Isidro Metapán | 1:0 (0:0) | ||
| 2nd (2nd leg) | Isidro Metapán | - | Luis Ángel Firpo | 1:3 (1:1) | ||
| 1st(1st leg): 05/05/2021 21:30 | 2nd (2nd leg): 09/05/2021 02:15 | Winner: Luis Ángel Firpo | ||||
| 1st(1st leg) | CD Águila | - | Alianza | 0:1 (0:0) | ||
| 2nd (2nd leg) | Alianza | - | CD Águila | 2:1 (0:1) | ||
| 1st(1st leg): 05/05/2021 22:00 | 2nd (2nd leg): 09/05/2021 22:15 | Winner: Alianza | ||||
| 1st(1st leg) | FAS | - | Municipal Limeño | 2:1 (1:0) | ||
| 2nd (2nd leg) | Municipal Limeño | - | FAS | 2:4 (0:0, 2:1) pso | ||
| 1st(1st leg): 05/05/2021 22:30 | 2nd (2nd leg): 09/05/2021 22:00 | Winner: FAS | ||||
| 1st(1st leg) | Santa Tecla FC | - | Once Municipal | 1:1 (0:0) | ||
| 2nd (2nd leg) | Once Municipal | - | Santa Tecla FC | 1:2 (0:0) | ||
| 1st(1st leg): 06/05/2021 02:00 | 2nd (2nd leg): 09/05/2021 22:00 | Winner: Santa Tecla FC | ||||
