 |
 |
|
|
| 1st(1st leg) | Luis Ángel Firpo | - | CD Águila | 0:2 (0:0) | ||
| 2nd (2nd leg) | CD Águila | - | Luis Ángel Firpo | 1:0 (1:0) | ||
| 1st(1st leg): 13/01/2021 21:30 | 2nd (2nd leg): 16/01/2021 21:30 | Winner: CD Águila | ||||
| 1st(1st leg) | Once Municipal | - | Alianza | 1:2 (1:2) | ||
| 2nd (2nd leg) | Alianza | - | Once Municipal | 3:1 (1:1) | ||
| 1st(1st leg): 13/01/2021 21:30 | 2nd (2nd leg): 17/01/2021 21:00 | Winner: Alianza | ||||
| 1st(1st leg) | Jocoro FC | - | Municipal Limeño | 0:0 (0:0) | ||
| 2nd (2nd leg) | Municipal Limeño | - | Jocoro FC | 1:2 (1:1) | ||
| 1st(1st leg): 14/01/2021 21:15 | 2nd (2nd leg): 17/01/2021 20:30 | Winner: Jocoro FC | ||||
| 1st(1st leg) | Sonsonate FC | - | FAS | 0:1 (0:1) | ||
| 2nd (2nd leg) | FAS | - | Sonsonate FC | 2:2 (2:1) | ||
| 1st(1st leg): 15/01/2021 01:00 | 2nd (2nd leg): 17/01/2021 21:00 | Winner: FAS | ||||
