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| 21/05/2022 | 09:00 | Akademiya Konopleva | - | Lokomotiv Moskva | 1:6 (1:1) | |
| 09:00 | CSKA Moskva | - | FK Strogino Moskva | 3:1 (2:1) | ||
| 09:00 | Dinamo Moskva | - | Chertanovo Football Academy | 2:2 (1:0) | ||
| 09:00 | Spartak Moskva | - | FK Rostov | 0:3 (0:1) | ||
| 09:00 | Uor-5 Egorievsk | - | SShOR Zenit | 3:2 (1:1) | ||
| 09:00 | Rubin Kazan | - | FK Krasnodar | 0:3 (0:2) | ||
| 09:00 | Zenit St. Petersburg | - | FShM Moskva | 7:0 (2:0) |
| » Tables | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Lokomotiv Moskva | 26 | 19 | 2 | 5 | 85:27 | 58 | 59 |
| 2 |
|
Zenit St. Petersburg | 26 | 17 | 4 | 5 | 75:33 | 42 | 55 |
| 3 |
|
Dinamo Moskva | 26 | 16 | 4 | 6 | 64:32 | 32 | 52 |
| 4 |
|
FK Krasnodar | 26 | 16 | 4 | 6 | 61:29 | 32 | 52 |
| 5 |
|
CSKA Moskva | 26 | 15 | 3 | 8 | 73:38 | 35 | 48 |
| 6 |
|
FK Rostov | 26 | 12 | 5 | 9 | 49:45 | 4 | 41 |
| 7 |
|
Chertanovo Football Academy | 26 | 9 | 10 | 7 | 55:57 | -2 | 37 |
| 8 |
|
Rubin Kazan | 26 | 10 | 6 | 10 | 47:52 | -5 | 36 |
| 9 |
|
Spartak Moskva | 26 | 11 | 3 | 12 | 47:55 | -8 | 36 |
| 10 |
|
Akademiya Konopleva | 26 | 9 | 2 | 15 | 41:63 | -22 | 29 |
| 11 |
|
Uor-5 Egorievsk | 26 | 7 | 6 | 13 | 38:67 | -29 | 27 |
| 12 |
|
SShOR Zenit | 26 | 5 | 2 | 19 | 26:64 | -38 | 17 |
| 13 |
|
FShM Moskva | 26 | 5 | 2 | 19 | 26:69 | -43 | 17 |
| 14 |
|
FK Strogino Moskva | 26 | 3 | 3 | 20 | 32:88 | -56 | 12 |
