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| 1st(1st leg) | TuS Röllbach | - | Vatan Spor Aschaffenburg | 2:2 | ||
| 2nd (2nd leg) | Vatan Spor Aschaffenburg | - | TuS Röllbach | 2:3 | ||
| 1st(1st leg): 25/05/2022 17:30 | 2nd (2nd leg): 28/05/2022 15:00 | Winner: TuS Röllbach | ||||
| 1st(1st leg) | TSV Karlburg | - | Würzburger FV | 1:3 | ||
| 2nd (2nd leg) | Würzburger FV | - | TSV Karlburg | 4:1 | ||
| 1st(1st leg): 25/05/2022 17:30 | 2nd (2nd leg): 28/05/2022 15:00 | Winner: Würzburger FV | ||||
| 1st(1st leg) | Fortuna Regensburg | - | VfB Hallbergmoos | 2:2 | ||
| 2nd (2nd leg) | VfB Hallbergmoos | - | Fortuna Regensburg | 3:0 | ||
| 1st(1st leg): 25/05/2022 17:30 | 2nd (2nd leg): 28/05/2022 15:00 | Winner: VfB Hallbergmoos | ||||
| 1st(1st leg) | TSV Neudrossenfeld | - | SV Seligenporten | 1:0 | ||
| 2nd (2nd leg) | SV Seligenporten | - | TSV Neudrossenfeld | 1:2 | ||
| 1st(1st leg): 25/05/2022 17:30 | 2nd (2nd leg): 28/05/2022 15:00 | Winner: TSV Neudrossenfeld | ||||
| 1st(1st leg) | FC Unterföhring | - | SV Pullach | 1:4 | ||
| 2nd (2nd leg) | SV Pullach | - | FC Unterföhring | 3:2 | ||
| 1st(1st leg): 25/05/2022 17:30 | 2nd (2nd leg): 28/05/2022 15:00 | Winner: SV Pullach | ||||
| 1st(1st leg) | 1. FC Sonthofen | - | TSV 1865 Dachau | 2:1 | ||
| 2nd (2nd leg) | TSV 1865 Dachau | - | 1. FC Sonthofen | 3:0 | ||
| 1st(1st leg): 25/05/2022 17:30 | 2nd (2nd leg): 28/05/2022 15:00 | Winner: TSV 1865 Dachau | ||||
