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| 28/08/2021 | 13:00 | FC 08 Homburg | - | 1899 Hoffenheim II | 3:3 (3:1) | |
| 13:00 | FC Gießen | - | FK Pirmasens | 0:1 (0:0) | ||
| 13:00 | FSV Frankfurt | - | Hessen Kassel | 1:0 (0:0) | ||
| 13:00 | Kickers Offenbach | - | SSV Ulm 1846 | 1:2 (1:0) | ||
| 13:00 | SV 07 Elversberg | - | Rot-Weiß Koblenz | 4:1 (2:0) | ||
| 13:00 | TSV Steinbach Haiger | - | TSV Schott Mainz | 3:2 (3:1) | ||
| 13:00 | VfR Aalen | - | Bahlinger SC | 2:3 (1:0) | ||
| 29/08/2021 | 13:00 | SG Sonnenhof Großaspach | - | 1. FSV Mainz 05 II | 1:3 (0:3) | |
| 13:00 | VfB Stuttgart II | - | FC-Astoria Walldorf | 2:3 (1:1) |
| » Tables | Home | Away | First round | Second round | First half | Second half |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
1. FSV Mainz 05 II | 4 | 4 | 0 | 0 | 9:3 | 6 | 12 |
| 2 |
|
FK Pirmasens | 4 | 3 | 1 | 0 | 4:1 | 3 | 10 |
| 3 |
|
1899 Hoffenheim II | 4 | 2 | 2 | 0 | 10:6 | 4 | 8 |
| 4 |
|
SSV Ulm 1846 | 4 | 2 | 2 | 0 | 12:9 | 3 | 8 |
| 5 |
|
SG Sonnenhof Großaspach | 4 | 2 | 1 | 1 | 9:5 | 4 | 7 |
| 6 |
|
Bahlinger SC | 3 | 2 | 1 | 0 | 5:3 | 2 | 7 |
| 7 |
|
Kickers Offenbach | 3 | 2 | 0 | 1 | 4:3 | 1 | 6 |
| 8 |
|
Rot-Weiß Koblenz | 4 | 2 | 0 | 2 | 6:7 | -1 | 6 |
| 9 |
|
TSV Steinbach Haiger | 4 | 1 | 2 | 1 | 5:5 | 0 | 5 |
| 10 |
|
FSV Frankfurt | 4 | 1 | 1 | 2 | 5:7 | -2 | 4 |
| 11 |
|
TSV Schott Mainz | 4 | 1 | 1 | 2 | 4:6 | -2 | 4 |
| 12 |
|
Hessen Kassel | 4 | 1 | 1 | 2 | 5:8 | -3 | 4 |
| 13 |
|
FC-Astoria Walldorf | 4 | 1 | 1 | 2 | 3:6 | -3 | 4 |
| 14 |
|
SV 07 Elversberg | 3 | 1 | 0 | 2 | 7:7 | 0 | 3 |
| 15 |
|
VfB Stuttgart II | 4 | 1 | 0 | 3 | 8:9 | -1 | 3 |
| 16 |
|
VfR Aalen | 4 | 1 | 0 | 3 | 6:8 | -2 | 3 |
| 17 |
|
FC Gießen | 4 | 1 | 0 | 3 | 1:3 | -2 | 3 |
| 18 |
|
FC 08 Homburg | 4 | 0 | 2 | 2 | 6:11 | -5 | 2 |
| 19 |
|
TSG Balingen | 3 | 0 | 1 | 2 | 2:4 | -2 | 1 |
| Promotion | |
| Relegation |
