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| 1st(1st leg) | União da Madeira | - | CS Marítimo | 2:3 | ||
| 2nd (2nd leg) | CS Marítimo | - | União da Madeira | 2:0 | ||
| 1st(1st leg): 08/10/2011 16:00 | 2nd (2nd leg): 12/11/2011 16:00 | Winner: CS Marítimo | ||||
| 1st(1st leg) | FC Penafiel | - | Académica de Coimbra | 1:1 (1:0) | ||
| 2nd (2nd leg) | Académica de Coimbra | - | FC Penafiel | 0:1 | ||
| 1st(1st leg): 08/10/2011 20:15 | 2nd (2nd leg): 13/11/2011 19:15 | Winner: FC Penafiel | ||||
| 1st(1st leg) | CD Santa Clara | - | União Leiria | 3:1 | ||
| 2nd (2nd leg) | União Leiria | - | CD Santa Clara | 1:0 | ||
| 1st(1st leg): 09/10/2011 17:00 | 2nd (2nd leg): 13/11/2011 16:00 | Winner: CD Santa Clara | ||||
| 1st(1st leg) | Naval 1° de Maio | - | Vitória Setúbal | 1:2 | ||
| 2nd (2nd leg) | Vitória Setúbal | - | Naval 1° de Maio | 2:1 | ||
| 1st(1st leg): 26/10/2011 16:00 | 2nd (2nd leg): 09/11/2011 16:00 | Winner: Vitória Setúbal | ||||
| 1st(1st leg) | Portimonense SC | - | CD Feirense | 1:0 | ||
| 2nd (2nd leg) | CD Feirense | - | Portimonense SC | 4:5 pso | ||
| 1st(1st leg): 26/10/2011 16:00 | 2nd (2nd leg): 09/11/2011 16:00 | Winner: Portimonense SC | ||||
| 1st(1st leg) | Moreirense FC | - | SC Beira-Mar | 2:2 | ||
| 2nd (2nd leg) | SC Beira-Mar | - | Moreirense FC | 1:2 | ||
| 1st(1st leg): 26/10/2011 16:00 | 2nd (2nd leg): 12/11/2011 16:00 | Winner: Moreirense FC | ||||
| 1st(1st leg) | GD Estoril | - | SC Olhanense | 3:3 | ||
| 2nd (2nd leg) | SC Olhanense | - | GD Estoril | 0:0 | ||
| 1st(1st leg): 26/10/2011 19:00 | 2nd (2nd leg): 09/11/2011 20:15 | Winner: SC Olhanense | ||||
| 1st(1st leg) | Os Belenenses | - | Gil Vicente | 2:1 | ||
| 2nd (2nd leg) | Gil Vicente | - | Os Belenenses | 2:0 | ||
| 1st(1st leg): 27/10/2011 16:00 | 2nd (2nd leg): 12/11/2011 20:15 | Winner: Gil Vicente | ||||
