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| 21/12/2021 | 18:45 | CD Tondela | - | GD Estoril | 3:1 (1:1) | |
| 20:45 | FC Famalicão | - | Portimonense SC | 2:4 (0:1, 1:1, 1:1) pso | ||
| 22/12/2021 | 14:00 | Leça FC | - | USC Paredes | 6:5 (1:1, 1:1, 1:1) pso | |
| 20:45 | Casa Pia AC | - | Sporting CP | 1:2 (1:1) | ||
| 23/12/2021 | 11:00 | CD Mafra | - | Moreirense FC | 3:1 (1:1) | |
| 17:00 | Rio Ave FC | - | Belenenses SAD | 6:5 (1:1, 1:1, 1:1) pso | ||
| 18:45 | FC Vizela | - | Sporting Braga | 1:0 (1:0) | ||
| 20:45 | FC Porto | - | SL Benfica | 3:0 (3:0) |
