 |
 |
|
|
| 20/04/2022 | 01:00 | Club Olimpia | - | Guaraní | 1:0 (1:0) | |
| 23:00 | Club Nacional | - | Guaireña FC | 3:1 (2:0) | ||
| 23:00 | General Caballero DJLM | - | 12 de Octubre de Itauguá | 0:0 (0:0) | ||
| 21/04/2022 | 01:15 | Libertad | - | Resistencia SC | 2:2 (1:0) | |
| 23:00 | Tacuary | - | Cerro Porteño | 2:0 (1:0) | ||
| 22/04/2022 | 01:15 | Sportivo Ameliano | - | Sol de América | 3:1 (1:1) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Libertad | 11 | 8 | 2 | 1 | 25:12 | 13 | 26 |
| 2 |
|
Cerro Porteño | 11 | 8 | 1 | 2 | 23:8 | 15 | 25 |
| 3 |
|
Resistencia SC | 11 | 5 | 5 | 1 | 21:16 | 5 | 20 |
| 4 |
|
Club Olimpia | 11 | 5 | 3 | 3 | 15:11 | 4 | 18 |
| 5 |
|
Club Nacional | 11 | 5 | 2 | 4 | 16:17 | -1 | 17 |
| 6 |
|
Sol de América | 11 | 4 | 2 | 5 | 9:15 | -6 | 14 |
| 7 |
|
Tacuary | 11 | 4 | 1 | 6 | 9:11 | -2 | 13 |
| 8 |
|
Guaireña FC | 11 | 3 | 3 | 5 | 10:15 | -5 | 12 |
| 9 |
|
Guaraní | 11 | 3 | 2 | 6 | 11:14 | -3 | 11 |
| 10 |
|
General Caballero DJLM | 11 | 2 | 3 | 6 | 10:14 | -4 | 9 |
| 11 |
|
Sportivo Ameliano | 11 | 3 | 0 | 8 | 12:19 | -7 | 9 |
| 12 |
|
12 de Octubre de Itauguá | 11 | 1 | 6 | 4 | 8:17 | -9 | 9 |
| Copa Libertadores |
