 |
 |
|
|
| 11/09/2021 | 00:30 | Club Nacional | - | Sol de América | 1:1 (1:1) | |
| 23:00 | Sportivo Luqueño | - | River Plate | 0:2 (0:2) | ||
| 12/09/2021 | 01:15 | Guaraní | - | Guaireña FC | 3:0 (2:0) | |
| 22:00 | 12 de Octubre de Itauguá | - | Cerro Porteño | 0:1 (0:0) | ||
| 13/09/2021 | 00:15 | Libertad | - | Club Olimpia | 0:3 (0:2) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Guaraní | 8 | 6 | 2 | 0 | 25:7 | 18 | 20 |
| 2 |
|
Cerro Porteño | 8 | 4 | 3 | 1 | 9:4 | 5 | 15 |
| 3 |
|
River Plate | 8 | 4 | 2 | 2 | 11:10 | 1 | 14 |
| 4 |
|
Sol de América | 8 | 3 | 3 | 2 | 8:9 | -1 | 12 |
| 5 |
|
Sportivo Luqueño | 8 | 3 | 1 | 4 | 7:14 | -7 | 10 |
| 6 |
|
Club Nacional | 8 | 2 | 3 | 3 | 8:9 | -1 | 9 |
| 7 |
|
Libertad | 8 | 1 | 5 | 2 | 12:11 | 1 | 8 |
| 8 |
|
Guaireña FC | 8 | 2 | 2 | 4 | 6:9 | -3 | 8 |
| 9 |
|
12 de Octubre de Itauguá | 8 | 1 | 3 | 4 | 10:16 | -6 | 6 |
| 10 |
|
Club Olimpia | 8 | 2 | 0 | 6 | 8:15 | -7 | 6 |
| 11 |
|
Deportivo Recoleta | 0 | 0 | 0 | 0 | 0:0 | 0 | 0 |
| Copa Libertadores |
