 |
 |
|
|
| 05/11/2021 | 22:00 | River Plate | - | 12 de Octubre de Itauguá | 0:2 (0:1) | |
| 07/11/2021 | 21:15 | Libertad | - | Guaraní | 2:0 (0:0) | |
| 23:30 | Cerro Porteño | - | Sol de América | 3:0 (2:0) | ||
| 08/11/2021 | 21:15 | Club Olimpia | - | Sportivo Luqueño | 4:0 (0:0) | |
| 23:30 | Guaireña FC | - | Club Nacional | 0:0 (0:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Guaraní | 15 | 9 | 4 | 2 | 34:15 | 19 | 31 |
| 2 |
|
Cerro Porteño | 15 | 9 | 4 | 2 | 19:5 | 14 | 31 |
| 3 |
|
Sol de América | 15 | 6 | 4 | 5 | 18:21 | -3 | 22 |
| 4 |
|
Libertad | 15 | 5 | 5 | 5 | 22:17 | 5 | 20 |
| 5 |
|
Club Nacional | 15 | 4 | 8 | 3 | 15:14 | 1 | 20 |
| 6 |
|
Sportivo Luqueño | 15 | 5 | 4 | 6 | 14:24 | -10 | 19 |
| 7 |
|
12 de Octubre de Itauguá | 15 | 4 | 5 | 6 | 17:21 | -4 | 17 |
| 8 |
|
River Plate | 15 | 4 | 4 | 7 | 14:21 | -7 | 16 |
| 9 |
|
Club Olimpia | 15 | 5 | 0 | 10 | 19:24 | -5 | 15 |
| 10 |
|
Guaireña FC | 15 | 3 | 4 | 8 | 10:20 | -10 | 13 |
| 11 |
|
Deportivo Recoleta | 0 | 0 | 0 | 0 | 0:0 | 0 | 0 |
| Copa Libertadores |
