 |
 |
|
|
| 23/10/2021 | 22:00 | River Plate | - | Sol de América | 0:2 (0:1) | |
| 24/10/2021 | 00:15 | Sportivo Luqueño | - | 12 de Octubre de Itauguá | 0:0 (0:0) | |
| 22:00 | Club Olimpia | - | Guaraní | 1:3 (1:1) | ||
| 25/10/2021 | 00:15 | Libertad | - | Club Nacional | 1:2 (0:1) | |
| 22:30 | Guaireña FC | - | Cerro Porteño | 0:2 (0:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Guaraní | 13 | 8 | 4 | 1 | 32:12 | 20 | 28 |
| 2 |
|
Cerro Porteño | 13 | 7 | 4 | 2 | 15:5 | 10 | 25 |
| 3 |
|
Sol de América | 13 | 5 | 4 | 4 | 15:18 | -3 | 19 |
| 4 |
|
Sportivo Luqueño | 13 | 5 | 4 | 4 | 13:18 | -5 | 19 |
| 5 |
|
Club Nacional | 13 | 4 | 6 | 3 | 14:13 | 1 | 18 |
| 6 |
|
River Plate | 13 | 4 | 3 | 6 | 13:18 | -5 | 15 |
| 7 |
|
Libertad | 13 | 3 | 5 | 5 | 19:17 | 2 | 14 |
| 8 |
|
12 de Octubre de Itauguá | 13 | 3 | 5 | 5 | 15:20 | -5 | 14 |
| 9 |
|
Guaireña FC | 13 | 3 | 3 | 7 | 10:17 | -7 | 12 |
| 10 |
|
Club Olimpia | 13 | 4 | 0 | 9 | 15:23 | -8 | 12 |
| 11 |
|
Deportivo Recoleta | 0 | 0 | 0 | 0 | 0:0 | 0 | 0 |
| Copa Libertadores |
