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| 13/10/2021 | 19:45 | Carrick Rangers | - | Coleraine FC | 0:2 | |
| 19:45 | Crusaders FC | - | Ballymena United | 2:3 aet | ||
| 19:45 | Glenavon FC | - | Glentoran FC | 4:5 pso | ||
| 19:45 | Warrenpoint Town | - | Loughgall FC | 1:0 | ||
| 26/10/2021 | 19:45 | Portadown FC | - | Ballinamallard United FC | 1:0 | |
| 20:00 | Ards FC | - | Cliftonville FC | 1:4 | ||
| 02/11/2021 | 19:45 | Limavady United | - | Dungannon Swifts | 3:2 | |
| 19:45 | Linfield FC | - | PSNI FC | 11:0 |
