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| 1st(1st leg) | sc Heerenveen | - | AZ Alkmaar | 3:2 (0:0) | ||
| 2nd (2nd leg) | AZ Alkmaar | - | sc Heerenveen | 2:0 (1:0) | ||
| 1st(1st leg): 19/05/2022 17:45 | 2nd (2nd leg): 22/05/2022 13:30 | Winner: AZ Alkmaar | ||||
| 1st(1st leg) | FC Utrecht | - | Vitesse | 3:1 (2:0) | ||
| 2nd (2nd leg) | Vitesse | - | FC Utrecht | 3:0 (1:0, 2:0) aet | ||
| 1st(1st leg): 19/05/2022 20:00 | 2nd (2nd leg): 22/05/2022 17:00 | Winner: Vitesse | ||||
