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| 1st(1st leg) | Telstar | - | De Graafschap | 3:2 (1:0) | ||
| 2nd (2nd leg) | De Graafschap | - | Telstar | 4:2 (2:0) | ||
| 1st(1st leg): 10/05/2018 11:30 | 2nd (2nd leg): 13/05/2018 11:30 | Winner: De Graafschap | ||||
| 1st(1st leg) | FC Emmen | - | NEC Nijmegen | 4:0 (3:0) | ||
| 2nd (2nd leg) | NEC Nijmegen | - | FC Emmen | 4:1 (4:1) | ||
| 1st(1st leg): 10/05/2018 13:30 | 2nd (2nd leg): 13/05/2018 13:30 | Winner: FC Emmen | ||||
| 1st(1st leg) | FC Dordrecht | - | Sparta Rotterdam | 1:2 (0:1) | ||
| 2nd (2nd leg) | Sparta Rotterdam | - | FC Dordrecht | 2:2 (0:2) | ||
| 1st(1st leg): 10/05/2018 15:45 | 2nd (2nd leg): 13/05/2018 15:45 | Winner: Sparta Rotterdam | ||||
| 1st(1st leg) | Almere City FC | - | Roda JC Kerkrade | 0:0 (0:0) | ||
| 2nd (2nd leg) | Roda JC Kerkrade | - | Almere City FC | 1:2 (0:1) | ||
| 1st(1st leg): 10/05/2018 19:00 | 2nd (2nd leg): 13/05/2018 19:00 | Winner: Almere City FC | ||||
