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| 1st(1st leg) | FC Volendam | - | VVV-Venlo | 1:2 (0:1) | ||
| 2nd (2nd leg) | VVV-Venlo | - | FC Volendam | 2:0 (1:0) | ||
| 1st(1st leg): 19/05/2011 17:45 | 2nd (2nd leg): 22/05/2011 13:30 | Winner: VVV-Venlo | ||||
| 1st(1st leg) | FC Den Bosch | - | SBV Excelsior | 3:3 (1:1) | ||
| 2nd (2nd leg) | SBV Excelsior | - | FC Den Bosch | 3:1 (1:0) | ||
| 1st(1st leg): 19/05/2011 17:45 | 2nd (2nd leg): 22/05/2011 15:30 | Winner: SBV Excelsior | ||||
| 1st(1st leg) | SC Cambuur | - | FC Zwolle | 2:1 (0:0) | ||
| 2nd (2nd leg) | FC Zwolle | - | SC Cambuur | 7:6 (0:1, 2:1, 2:1) pso | ||
| 1st(1st leg): 19/05/2011 19:00 | 2nd (2nd leg): 22/05/2011 13:30 | Winner: FC Zwolle | ||||
| 1st(1st leg) | BV Veendam | - | Helmond Sport | 3:3 (3:0) | ||
| 2nd (2nd leg) | Helmond Sport | - | BV Veendam | 1:0 (0:0) | ||
| 1st(1st leg): 19/05/2011 19:00 | 2nd (2nd leg): 22/05/2011 13:30 | Winner: Helmond Sport | ||||
