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| 24/10/2017 | 17:30 | NEC Nijmegen | - | Achilles'29 | 3:0 (1:0) | |
| 18:45 | Fortuna Sittard | - | Go Ahead Eagles | 3:0 (1:0) | ||
| 18:45 | PEC Zwolle | - | Kozakken Boys | 3:2 (1:0, 2:2, 3:2) aet | ||
| 18:45 | VV Katwijk | - | VV Sint Bavo | 1:2 (0:0) | ||
| 18:45 | GVVV | - | Koninklijke HFC | 1:0 (0:0) | ||
| 18:45 | RKC Waalwijk | - | De Treffers | 7:0 (3:0) | ||
| 18:45 | FC Den Bosch | - | SC Cambuur | 0:2 (0:0) | ||
| 19:45 | FC Twente | - | FC Eindhoven | 3:0 (1:0) | ||
| 25/10/2017 | 17:30 | Heracles Almelo | - | HSV Hoek | 3:1 (2:0) | |
| 17:30 | VVV-Venlo | - | FC Utrecht | 3:1 (2:0) | ||
| 17:30 | ASV De Dijk | - | AFC Ajax | 1:4 (0:3) | ||
| 18:45 | Willem II | - | sc Heerenveen | 2:1 (0:0) | ||
| 18:45 | Roda JC Kerkrade | - | FC Groningen | 3:1 (1:0) | ||
| 19:45 | Feyenoord | - | AVV Swift | 4:1 (2:0) | ||
| 26/10/2017 | 17:30 | FC Volendam | - | PSV Eindhoven | 0:2 (0:0, 0:0, 0:2) aet | |
| 19:45 | Almere City FC | - | AZ Alkmaar | 0:4 (0:1) |
