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| 15/12/2015 | 17:30 | HHC Hardenberg | - | NEC Nijmegen | 2:0 (0:0) | |
| 19:00 | Excelsior '31 | - | FC Den Bosch | 1:3 (1:1) | ||
| 19:45 | Roda JC Kerkrade | - | sc Heerenveen | 3:1 (2:0) | ||
| 16/12/2015 | 17:30 | Achilles'29 | - | FC Utrecht | 0:5 (0:2) | |
| 18:45 | Kozakken Boys | - | AZ Alkmaar | 1:3 (0:1) | ||
| 19:00 | VV Capelle | - | VV Sint Bavo | 2:3 (1:0) | ||
| 19:45 | Heracles Almelo | - | PSV Eindhoven | 2:3 (1:1) | ||
| 17/12/2015 | 19:45 | Feyenoord | - | Willem II | 2:1 (0:1, 1:1) aet |
