 |
 |
|
|
| 1st(1st leg) | CD Walter Ferretti | - | Real Estelí FC | 2:3 (2:1) | ||
| 2nd (2nd leg) | Real Estelí FC | - | CD Walter Ferretti | 0:2 (0:0, 0:1, 0:2) aet | ||
| 1st(1st leg): 08/05/2022 23:00 | 2nd (2nd leg): 12/05/2022 02:00 | Winner: CD Walter Ferretti | ||||
| 1st(1st leg) | Managua FC | - | Diriangén FC | 1:1 (0:1) | ||
| 2nd (2nd leg) | Diriangén FC | - | Managua FC | 1:0 (0:0, 0:0, 1:0) aet | ||
| 1st(1st leg): 09/05/2022 03:00 | 2nd (2nd leg): 12/05/2022 03:00 | Winner: Diriangén FC | ||||
