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| 1st(1st leg) | Managua FC | - | Diriangén FC | 1:2 (0:0) | ||
| 2nd (2nd leg) | Diriangén FC | - | Managua FC | 2:0 (0:0) | ||
| 1st(1st leg): 27/11/2021 23:00 | 2nd (2nd leg): 06/12/2021 00:00 | Winner: Diriangén FC | ||||
| 1st(1st leg) | CD Walter Ferretti | - | Real Estelí FC | 1:4 (1:2) | ||
| 2nd (2nd leg) | Real Estelí FC | - | CD Walter Ferretti | 2:0 (2:0) | ||
| 1st(1st leg): 29/11/2021 00:00 | 2nd (2nd leg): 05/12/2021 00:00 | Winner: Real Estelí FC | ||||
