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| 1st(1st leg) | CD Walter Ferretti | - | Diriangén FC | 1:0 (0:0) | ||
| 2nd (2nd leg) | Diriangén FC | - | CD Walter Ferretti | 3:0 (1:0) | ||
| 1st(1st leg): 13/05/2021 02:00 | 2nd (2nd leg): 16/05/2021 02:00 | Winner: Diriangén FC | ||||
| 1st(1st leg) | Managua FC | - | Real Estelí FC | 3:1 (3:1) | ||
| 2nd (2nd leg) | Real Estelí FC | - | Managua FC | 4:2 (2:0) | ||
| 1st(1st leg): 14/05/2021 02:00 | 2nd (2nd leg): 17/05/2021 02:00 | Winner: Managua FC | ||||
