 |
 |
|
|
| 26/03/2022 | 15:00 | CF Monterrey | - | Santos Laguna | 1:2 (0:2) | |
| 07/04/2022 | 15:00 | Atlas Guadalajara | - | Club Necaxa | 1:1 (0:0) | |
| 08/04/2022 | 16:00 | Puebla FC | - | Pumas UNAM | 2:2 (1:1) | |
| 17:00 | Mazatlán FC | - | Cruz Azul | 0:0 (0:0) | ||
| 09/04/2022 | 16:00 | Atlético San Luis | - | Club León | 1:1 (0:1) | |
| 16:00 | Deportivo Toluca | - | Deportivo Guadalajara | 1:1 (1:0) | ||
| 16:00 | CF América | - | FC Juárez | 6:0 (1:0) | ||
| 10/04/2022 | 15:00 | Gallos Blancos | - | UANL Tigres | 0:1 (0:0) | |
| 11/04/2022 | 18:00 | CF Pachuca | - | Club Tijuana | 0:0 (0:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club León | 13 | 8 | 2 | 3 | 23:14 | 9 | 26 |
| 2 |
|
CF Pachuca | 13 | 8 | 2 | 3 | 22:13 | 9 | 26 |
| 3 |
|
CF América | 13 | 8 | 1 | 4 | 27:11 | 16 | 25 |
| 4 |
|
Club Tijuana | 13 | 7 | 3 | 3 | 19:15 | 4 | 24 |
| 5 |
|
Deportivo Guadalajara | 13 | 7 | 3 | 3 | 15:13 | 2 | 24 |
| 6 |
|
Santos Laguna | 13 | 7 | 2 | 4 | 17:17 | 0 | 23 |
| 7 |
|
Deportivo Toluca | 13 | 6 | 4 | 3 | 20:15 | 5 | 22 |
| 8 |
|
Atlético San Luis | 13 | 6 | 2 | 5 | 27:19 | 8 | 20 |
| 9 |
|
UANL Tigres | 13 | 6 | 2 | 5 | 21:15 | 6 | 20 |
| 10 |
|
Cruz Azul | 13 | 4 | 5 | 4 | 12:10 | 2 | 17 |
| 11 |
|
Club Necaxa | 13 | 5 | 2 | 6 | 19:19 | 0 | 17 |
| 12 |
|
Mazatlán FC | 13 | 5 | 2 | 6 | 14:19 | -5 | 17 |
| 13 |
|
Pumas UNAM | 13 | 4 | 4 | 5 | 16:15 | 1 | 16 |
| 14 |
|
CF Monterrey | 13 | 4 | 3 | 6 | 15:22 | -7 | 15 |
| 15 |
|
Atlas Guadalajara | 13 | 2 | 4 | 7 | 9:18 | -9 | 10 |
| 16 |
|
FC Juárez | 13 | 2 | 4 | 7 | 12:30 | -18 | 10 |
| 17 |
|
Puebla FC | 13 | 2 | 2 | 9 | 13:28 | -15 | 8 |
| 18 |
|
Gallos Blancos | 13 | 1 | 3 | 9 | 6:14 | -8 | 6 |
| Playoffs |
