 |
 |
|
| 04/11/2021 | 15:00 | Atlas Guadalajara | - | Gallos Blancos | 1:1 (1:0) | |
| 05/11/2021 | 15:00 | Puebla FC | - | Deportivo Toluca | 0:3 (0:1) | |
| 15:30 | Mazatlán FC | - | Deportivo Guadalajara | 1:0 (0:0) | ||
| 06/11/2021 | 17:00 | CF América | - | CF Monterrey | 2:0 (2:0) | |
| 17:15 | UANL Tigres | - | FC Juárez | 1:0 (1:0) | ||
| 17:30 | Club León | - | Club Necaxa | 3:1 (2:1) | ||
| 07/11/2021 | 15:00 | Pumas UNAM | - | Cruz Azul | 1:2 (1:1) | |
| 17:00 | Santos Laguna | - | Atlético San Luis | 2:1 (0:0) | ||
| 10/11/2021 | 18:00 | Club Tijuana | - | CF Pachuca | 2:1 (1:0) |
| » Tables | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Santos Laguna | 17 | 10 | 4 | 3 | 38:21 | 17 | 34 |
| 2 |
|
Cruz Azul | 17 | 7 | 8 | 2 | 15:9 | 6 | 29 |
| 3 |
|
Deportivo Toluca | 17 | 9 | 2 | 6 | 24:19 | 5 | 29 |
| 4 |
|
CF América | 17 | 7 | 6 | 4 | 25:19 | 6 | 27 |
| 5 |
|
UANL Tigres | 17 | 8 | 2 | 7 | 24:19 | 5 | 26 |
| 6 |
|
Atlas Guadalajara | 17 | 7 | 5 | 5 | 23:21 | 2 | 26 |
| 7 |
|
Mazatlán FC | 17 | 7 | 4 | 6 | 31:30 | 1 | 25 |
| 8 |
|
Club León | 17 | 7 | 3 | 7 | 19:19 | 0 | 24 |
| 9 |
|
Atlético San Luis | 17 | 7 | 2 | 8 | 27:27 | 0 | 23 |
| 10 |
|
Deportivo Guadalajara | 17 | 7 | 2 | 8 | 22:26 | -4 | 23 |
| 11 |
|
CF Pachuca | 17 | 5 | 7 | 5 | 24:19 | 5 | 22 |
| 12 |
|
Puebla FC | 17 | 5 | 7 | 5 | 26:31 | -5 | 22 |
| 13 |
|
Pumas UNAM | 17 | 6 | 3 | 8 | 27:26 | 1 | 21 |
| 14 |
|
Club Necaxa | 17 | 5 | 6 | 6 | 25:28 | -3 | 21 |
| 15 |
|
Club Tijuana | 17 | 5 | 6 | 6 | 25:29 | -4 | 21 |
| 16 |
|
CF Monterrey | 17 | 5 | 4 | 8 | 25:25 | 0 | 19 |
| 17 |
|
Gallos Blancos | 17 | 4 | 6 | 7 | 19:29 | -10 | 18 |
| 18 |
|
FC Juárez | 17 | 1 | 5 | 11 | 11:33 | -22 | 8 |
| Playoffs |
