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| 1st(1st leg) | Monarcas Morelia | - | CF Monterrey | 1:2 (0:1) | ||
| 2nd (2nd leg) | CF Monterrey | - | Monarcas Morelia | 2:0 (0:0) | ||
| 1st(1st leg): 08/05/2019 16:00 | 2nd (2nd leg): 11/05/2019 15:00 | Winner: CF Monterrey | ||||
| 1st(1st leg) | CF América | - | Atlas Guadalajara | 1:2 (0:1) | ||
| 2nd (2nd leg) | Atlas Guadalajara | - | CF América | 1:0 (1:0) | ||
| 1st(1st leg): 08/05/2019 17:00 | 2nd (2nd leg): 11/05/2019 16:00 | Winner: Atlas Guadalajara | ||||
| 1st(1st leg) | UANL Tigres | - | CF Pachuca | 2:1 (0:0) | ||
| 2nd (2nd leg) | CF Pachuca | - | UANL Tigres | 2:2 (0:0) | ||
| 1st(1st leg): 08/05/2019 17:00 | 2nd (2nd leg): 11/05/2019 23:00 | Winner: UANL Tigres | ||||
| 1st(1st leg) | Deportivo Toluca | - | Santos Laguna | 2:1 (1:0) | ||
| 2nd (2nd leg) | Santos Laguna | - | Deportivo Toluca | 2:0 (1:0) | ||
| 1st(1st leg): 09/05/2019 15:00 | 2nd (2nd leg): 12/05/2019 17:15 | Winner: Santos Laguna | ||||
