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| 1st(1st leg) | Atlas Guadalajara | - | CF Monterrey | 2:1 (1:1) | ||
| 2nd (2nd leg) | CF Monterrey | - | Atlas Guadalajara | 2:0 (1:0) | ||
| 1st(1st leg): 03/05/2023 16:00 | 2nd (2nd leg): 06/05/2023 18:30 | Winner: CF Monterrey | ||||
| 1st(1st leg) | CF América | - | Cruz Azul | 2:1 (2:0) | ||
| 2nd (2nd leg) | Cruz Azul | - | CF América | 3:0 (2:0) | ||
| 1st(1st leg): 03/05/2023 18:00 | 2nd (2nd leg): 06/05/2023 16:30 | Winner: Cruz Azul | ||||
| 1st(1st leg) | Deportivo Guadalajara | - | UANL Tigres | 1:0 (1:0) | ||
| 2nd (2nd leg) | UANL Tigres | - | Deportivo Guadalajara | 1:2 (1:0) | ||
| 1st(1st leg): 04/05/2023 16:00 | 2nd (2nd leg): 07/05/2023 17:00 | Winner: Deportivo Guadalajara | ||||
| 1st(1st leg) | Deportivo Toluca | - | Club Necaxa | 1:0 (0:0) | ||
| 2nd (2nd leg) | Club Necaxa | - | Deportivo Toluca | 2:1 (0:1) | ||
| 1st(1st leg): 04/05/2023 18:30 | 2nd (2nd leg): 07/05/2023 17:00 | Winner: Deportivo Toluca | ||||
