 |
 |
|
| 15/09/2021 | 17:00 | CF América | - | Santos Laguna | 0:1 (0:1) | |
| 21/09/2021 | 18:30 | FC Juárez | - | Atlético San Luis | 0:3 (0:2) | |
| 19/10/2021 | 17:30 | Atlas Guadalajara | - | Cruz Azul | 5:2 (0:0) | |
| 17:30 | Gallos Blancos | - | CF Monterrey | 1:0 (0:0) | ||
| 17:45 | Puebla FC | - | Mazatlán FC | 0:2 (0:0) | ||
| 20/10/2021 | 15:30 | UANL Tigres | - | CF Pachuca | 3:2 (2:1) | |
| 17:30 | Deportivo Toluca | - | Club Necaxa | 2:3 (0:3) | ||
| 17:30 | Club León | - | Pumas UNAM | 2:1 (2:1) | ||
| 20:45 | Club Tijuana | - | Deportivo Guadalajara | 1:3 (0:1) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club Necaxa | 14 | 10 | 3 | 1 | 38:23 | 15 | 33 |
| 2 |
|
Club León | 14 | 9 | 3 | 2 | 25:20 | 5 | 30 |
| 3 |
|
CF América | 14 | 9 | 2 | 3 | 26:15 | 11 | 29 |
| 4 |
|
UANL Tigres | 14 | 8 | 4 | 2 | 25:10 | 15 | 28 |
| 5 |
|
Mazatlán FC | 14 | 7 | 4 | 3 | 22:18 | 4 | 25 |
| 6 |
|
CF Pachuca | 14 | 7 | 3 | 4 | 31:16 | 15 | 24 |
| 7 |
|
Atlas Guadalajara | 14 | 6 | 4 | 4 | 25:20 | 5 | 22 |
| 8 |
|
Santos Laguna | 14 | 6 | 3 | 5 | 19:16 | 3 | 21 |
| 9 |
|
Gallos Blancos | 14 | 5 | 5 | 4 | 12:10 | 2 | 20 |
| 10 |
|
Deportivo Guadalajara | 14 | 4 | 6 | 4 | 26:23 | 3 | 18 |
| 11 |
|
Deportivo Toluca | 14 | 4 | 4 | 6 | 18:19 | -1 | 16 |
| 12 |
|
Club Tijuana | 14 | 5 | 1 | 8 | 20:25 | -5 | 16 |
| 13 |
|
Atlético San Luis | 14 | 4 | 4 | 6 | 22:33 | -11 | 16 |
| 14 |
|
FC Juárez | 14 | 4 | 3 | 7 | 22:22 | 0 | 15 |
| 15 |
|
Cruz Azul | 14 | 3 | 4 | 7 | 16:30 | -14 | 13 |
| 16 |
|
Pumas UNAM | 14 | 2 | 4 | 8 | 13:26 | -13 | 10 |
| 17 |
|
Puebla FC | 14 | 1 | 3 | 10 | 18:36 | -18 | 6 |
| 18 |
|
CF Monterrey | 14 | 0 | 4 | 10 | 8:24 | -16 | 4 |
| Playoffs |
