 |
 |
|
| 22/09/2021 | 17:30 | CF Monterrey | - | Deportivo Toluca | 2:3 (1:1) | |
| 28/09/2021 | 15:30 | CF Pachuca | - | CF América | 4:1 (3:0) | |
| 17:15 | Club Necaxa | - | Club Tijuana | 4:0 (1:0) | ||
| 17:30 | Atlas Guadalajara | - | Puebla FC | 2:2 (2:2) | ||
| 18:30 | Mazatlán FC | - | FC Juárez | 3:2 (3:2) | ||
| 29/09/2021 | 17:30 | Gallos Blancos | - | Deportivo Guadalajara | 1:1 (0:1) | |
| 17:45 | Atlético San Luis | - | UANL Tigres | 0:5 (0:3) | ||
| 03/11/2021 | 17:30 | Cruz Azul | - | Club León | 2:3 (2:1) | |
| 04/11/2021 | 17:30 | Pumas UNAM | - | Santos Laguna | 0:1 (0:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club Necaxa | 11 | 8 | 2 | 1 | 30:17 | 13 | 26 |
| 2 |
|
CF América | 11 | 8 | 1 | 2 | 24:13 | 11 | 25 |
| 3 |
|
CF Pachuca | 11 | 6 | 3 | 2 | 27:12 | 15 | 21 |
| 4 |
|
UANL Tigres | 11 | 6 | 3 | 2 | 20:7 | 13 | 21 |
| 5 |
|
Mazatlán FC | 11 | 6 | 3 | 2 | 19:14 | 5 | 21 |
| 6 |
|
Club León | 11 | 6 | 3 | 2 | 18:16 | 2 | 21 |
| 7 |
|
Atlas Guadalajara | 11 | 5 | 3 | 3 | 19:14 | 5 | 18 |
| 8 |
|
Deportivo Toluca | 11 | 4 | 3 | 4 | 14:13 | 1 | 15 |
| 9 |
|
Club Tijuana | 11 | 4 | 1 | 6 | 16:18 | -2 | 13 |
| 10 |
|
Cruz Azul | 11 | 3 | 4 | 4 | 12:21 | -9 | 13 |
| 11 |
|
FC Juárez | 11 | 3 | 3 | 5 | 19:17 | 2 | 12 |
| 12 |
|
Santos Laguna | 11 | 3 | 3 | 5 | 14:16 | -2 | 12 |
| 13 |
|
Atlético San Luis | 11 | 3 | 3 | 5 | 15:28 | -13 | 12 |
| 14 |
|
Deportivo Guadalajara | 11 | 2 | 5 | 4 | 18:20 | -2 | 11 |
| 15 |
|
Gallos Blancos | 11 | 2 | 5 | 4 | 8:10 | -2 | 11 |
| 16 |
|
Pumas UNAM | 11 | 1 | 4 | 6 | 10:23 | -13 | 7 |
| 17 |
|
Puebla FC | 11 | 1 | 3 | 7 | 15:28 | -13 | 6 |
| 18 |
|
CF Monterrey | 11 | 0 | 4 | 7 | 8:19 | -11 | 4 |
| Playoffs |
