 |
 |
| 04/11/2021 | 17:30 | Atlas Guadalajara | - | Gallos Blancos | 2:1 (1:1) | |
| 05/11/2021 | 17:15 | Puebla FC | - | Deportivo Toluca | 3:1 (2:1) | |
| 17:45 | Mazatlán FC | - | Deportivo Guadalajara | 2:1 (1:0) | ||
| 06/11/2021 | 15:00 | CF América | - | CF Monterrey | 2:0 (1:0) | |
| 15:00 | Club León | - | Club Necaxa | 3:2 (2:0) | ||
| 15:30 | UANL Tigres | - | FC Juárez | 2:0 (2:0) | ||
| 07/11/2021 | 15:00 | Santos Laguna | - | Atlético San Luis | 6:1 (2:1) | |
| 17:30 | Pumas UNAM | - | Cruz Azul | 2:2 (0:0) | ||
| 10/11/2021 | 20:30 | Club Tijuana | - | CF Pachuca | 2:2 (1:2) |
| » Tables | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club Necaxa | 17 | 12 | 3 | 2 | 46:27 | 19 | 39 |
| 2 |
|
Club León | 17 | 11 | 3 | 3 | 32:25 | 7 | 36 |
| 3 |
|
CF América | 17 | 10 | 4 | 3 | 31:18 | 13 | 34 |
| 4 |
|
UANL Tigres | 17 | 9 | 5 | 3 | 31:16 | 15 | 32 |
| 5 |
|
CF Pachuca | 17 | 9 | 4 | 4 | 37:18 | 19 | 31 |
| 6 |
|
Atlas Guadalajara | 17 | 9 | 4 | 4 | 29:21 | 8 | 31 |
| 7 |
|
Mazatlán FC | 17 | 9 | 4 | 4 | 26:22 | 4 | 31 |
| 8 |
|
Santos Laguna | 17 | 8 | 4 | 5 | 29:19 | 10 | 28 |
| 9 |
|
Deportivo Guadalajara | 17 | 6 | 6 | 5 | 32:27 | 5 | 24 |
| 10 |
|
Gallos Blancos | 17 | 5 | 6 | 6 | 14:15 | -1 | 21 |
| 11 |
|
Atlético San Luis | 17 | 5 | 4 | 8 | 26:41 | -15 | 19 |
| 12 |
|
Club Tijuana | 17 | 5 | 3 | 9 | 24:30 | -6 | 18 |
| 13 |
|
Deportivo Toluca | 17 | 4 | 4 | 9 | 21:28 | -7 | 16 |
| 14 |
|
FC Juárez | 17 | 4 | 3 | 10 | 22:29 | -7 | 15 |
| 15 |
|
Puebla FC | 17 | 4 | 3 | 10 | 25:38 | -13 | 15 |
| 16 |
|
Cruz Azul | 17 | 3 | 6 | 8 | 19:34 | -15 | 15 |
| 17 |
|
Pumas UNAM | 17 | 2 | 6 | 9 | 17:31 | -14 | 12 |
| 18 |
|
CF Monterrey | 17 | 0 | 4 | 13 | 10:32 | -22 | 4 |
| Playoffs |
