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| 1st(1st leg) | Santos Laguna | - | Atlas Guadalajara | 1:1 (1:1) | ||
| 2nd (2nd leg) | Atlas Guadalajara | - | Santos Laguna | 1:1 (0:1) | ||
| 1st(1st leg): 12/05/2021 15:00 | 2nd (2nd leg): 15/05/2021 15:00 | |||||
| 1st(1st leg) | Deportivo Guadalajara | - | CF Pachuca | 2:2 (0:0) | ||
| 2nd (2nd leg) | CF Pachuca | - | Deportivo Guadalajara | 1:2 (0:1) | ||
| 1st(1st leg): 12/05/2021 16:00 | 2nd (2nd leg): 15/05/2021 23:00 | Winner: Deportivo Guadalajara | ||||
