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| 1st(1st leg) | Deportivo Toluca | - | Club Necaxa | 0:0 (0:0) | ||
| 2nd (2nd leg) | Club Necaxa | - | Deportivo Toluca | 3:2 (1:1) | ||
| 1st(1st leg): 02/12/2020 17:30 | 2nd (2nd leg): 05/12/2020 18:00 | Winner: Club Necaxa | ||||
| 1st(1st leg) | Puebla FC | - | Atlas Guadalajara | 4:2 (2:2) | ||
| 2nd (2nd leg) | Atlas Guadalajara | - | Puebla FC | 2:1 (0:0) | ||
| 1st(1st leg): 02/12/2020 17:45 | 2nd (2nd leg): 05/12/2020 15:00 | Winner: Puebla FC | ||||
