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| 02/04/2022 | 16:00 | Cruz Azul | - | Deportivo Toluca | 0:1 (0:0) | |
| 16:00 | UANL Tigres | - | Atlético San Luis | 2:1 (1:0) | ||
| 16:00 | CF Monterrey | - | Santos Laguna | 2:1 (1:0) | ||
| 19:00 | Gallos Blancos | - | Puebla FC | 2:1 (1:1) | ||
| 19:00 | Club Tijuana | - | Atlas Guadalajara | 1:2 (0:2) | ||
| 19:30 | Mazatlán FC | - | Club León | 2:3 (0:3) | ||
| 03/04/2022 | 17:00 | FC Juárez | - | CF Pachuca | 1:2 (1:0) | |
| 18:30 | Club Necaxa | - | CF América | 2:1 (1:1) |
| » Tables | Home | Away | First round | Second round |
| 1 | |||||||||
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Cruz Azul | 12 | 7 | 2 | 3 | 29:17 | 12 | 23 |
| 2 |
|
Deportivo Toluca | 12 | 6 | 2 | 4 | 25:17 | 8 | 20 |
| 3 |
|
Pumas UNAM | 11 | 6 | 2 | 3 | 15:8 | 7 | 20 |
| 4 |
|
Club Necaxa | 11 | 5 | 4 | 2 | 17:18 | -1 | 19 |
| 5 |
|
CF Pachuca | 12 | 4 | 5 | 3 | 24:22 | 2 | 17 |
| 6 |
|
CF América | 11 | 5 | 1 | 5 | 15:14 | 1 | 16 |
| 7 |
|
Puebla FC | 12 | 4 | 2 | 6 | 20:19 | 1 | 14 |
| 8 |
|
Gallos Blancos | 12 | 2 | 3 | 7 | 9:23 | -14 | 9 |
| 9 |
|
FC Juárez | 11 | 2 | 1 | 8 | 15:31 | -16 | 7 |
| 2 | |||||||||
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 11 | 8 | 2 | 1 | 26:9 | 17 | 26 |
| 2 |
|
Atlas Guadalajara | 11 | 6 | 3 | 2 | 24:15 | 9 | 21 |
| 3 |
|
Santos Laguna | 12 | 6 | 2 | 4 | 19:14 | 5 | 20 |
| 4 |
|
UANL Tigres | 12 | 5 | 4 | 3 | 15:14 | 1 | 19 |
| 5 |
|
CF Monterrey | 12 | 3 | 6 | 3 | 18:15 | 3 | 15 |
| 6 |
|
Club León | 11 | 4 | 2 | 5 | 14:18 | -4 | 14 |
| 7 |
|
Club Tijuana | 11 | 4 | 1 | 6 | 10:17 | -7 | 13 |
| 8 |
|
Mazatlán FC | 12 | 2 | 3 | 7 | 15:28 | -13 | 9 |
| 9 |
|
Atlético San Luis | 12 | 1 | 3 | 8 | 10:21 | -11 | 6 |
| Playoffs | |
| Playoffs |
