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| 1st(1st leg) | CF Pachuca | - | Deportivo Guadalajara | 2:1 (0:0) | ||
| 2nd (2nd leg) | Deportivo Guadalajara | - | CF Pachuca | 1:0 (0:0) | ||
| 1st(1st leg): 09/12/2021 00:00 | 2nd (2nd leg): 11/12/2021 16:00 | Winner: Deportivo Guadalajara | ||||
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| 1st(1st leg) | CF Pachuca | - | Deportivo Guadalajara | 2:1 (0:0) | ||
| 2nd (2nd leg) | Deportivo Guadalajara | - | CF Pachuca | 1:0 (0:0) | ||
| 1st(1st leg): 09/12/2021 00:00 | 2nd (2nd leg): 11/12/2021 16:00 | Winner: Deportivo Guadalajara | ||||
