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| 1st(1st leg) | CF América | - | Deportivo Toluca | 2:0 (0:0) | ||
| 2nd (2nd leg) | Deportivo Toluca | - | CF América | 0:2 (0:0) | ||
| 1st(1st leg): 28/11/2024 01:00 | 2nd (2nd leg): 30/11/2024 23:00 | Winner: CF América | ||||
| 1st(1st leg) | Club Tijuana | - | Cruz Azul | 3:0 (3:0) | ||
| 2nd (2nd leg) | Cruz Azul | - | Club Tijuana | 3:0 (1:0) | ||
| 1st(1st leg): 28/11/2024 03:10 | 2nd (2nd leg): 01/12/2024 01:10 | |||||
| 1st(1st leg) | Atlético San Luis | - | UANL Tigres | 3:0 (1:0) | ||
| 2nd (2nd leg) | UANL Tigres | - | Atlético San Luis | 0:0 (0:0) | ||
| 1st(1st leg): 29/11/2024 01:00 | 2nd (2nd leg): 02/12/2024 01:00 | Winner: Atlético San Luis | ||||
| 1st(1st leg) | CF Monterrey | - | Pumas UNAM | 1:0 (0:0) | ||
| 2nd (2nd leg) | Pumas UNAM | - | CF Monterrey | 3:5 (1:1) | ||
| 1st(1st leg): 29/11/2024 03:10 | 2nd (2nd leg): 01/12/2024 18:00 | Winner: CF Monterrey | ||||
